Kenneth R. Chien and Masahiko Hoshijima are at the University of California San Diego Institute of Molecular Medicine, La Jolla, CA 92093, USA. kchien@ucsd.edu
The hyperplasia suppressor gene HSG, previously characterized for its function in mitochondrial fusion, has now been identified as a novel inhibitor of the Ras signalling pathway during smooth muscle cell proliferation. Because of the critical function of this process in atherosclerotic heart disease, these findings may have important clinical implications.
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