Seamus J. Martin is in the Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland. martinsj@tcd.ie
Proteins containing the BIR motif have been implicated as regulators of apoptosis and cell division. Apollon, an exceptionally large BIR-containing protein, inhibits apoptosis by targeting key cell death proteins for destruction by the ubiquitin-proteasome pathway. Now, deletion of apollon in the mouse has revealed a crucial function in cell division.
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