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Letter

Nature Cell Biology 6, 763–769 (1 August 2004) | doi:10.1038/ncb1153

The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor

Marcel Verg|[eacute]|s , Fr|[eacute]|d|[eacute]|ric Luton , Carmen Gruber , Frank Tiemann , Lorri G. Reinders , Lan Huang , Alma L. Burlingame , Carol R. Haft & Keith E. Mostov

Epithelial cells have separate apical and basolateral plasma membrane domains with distinct compositions. After delivery to one surface, proteins can be endocytosed and then recycled, degraded or transcytosed to the opposite surface.