1. Sharon A. White and Robin C. Allshire are at The Wellcome Trust Centre for Cell Biology, The Michael Swann Building, University of Edinburgh, Edinburgh EH9 3JR, UK. e-mail: sharon.a.white@ed.ac.uk and e-mail: robin.allshire@ed.ac.uk

Abstract

Centromeres, specialized regions on chromosomes, are essential for accurate chromosome segregation during cell division. In fission yeast, the RNA interference machinery has a pivotal function in the assembly of centromeric heterochromatin, which mediates sister centromere cohesion. Studies in vertebrate cells now suggest that many aspects of this process are conserved.

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