Developing Milestones - p563

doi:10.1038/ncb0704-563

Full Text - Developing Milestones | PDF (78 KB) - Developing Milestones

Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 - pp565 - 567

Elzbieta H Wloga, Vittoria Criniti, Roderick T. Bronson & Lili Yamasaki

doi:10.1038/ncb0704-565

Full Text - Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | PDF (149 KB) - Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | Supplementary information

Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 - pp567 - 568

D. E. Brash

doi:10.1038/ncb0704-567

Full Text - Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | PDF (149 KB) - Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1

Tangled NUDELs? - pp569 - 570

Erika L. F. Holzbaur

doi:10.1038/ncb0704-569

NUDEL was first identified as a protein required for nuclear migration in filamentous fungi. Now, a study shows that it is important for normal assembly of neurofilaments in the mammalian nervous system. In utero knockdown of NUDEL expression results in disruption of neurofilament organization.

Full Text - Tangled NUDELs? | PDF (113 KB) - Tangled NUDELs?

See also: Article by Nguyen et al.

Ubiquitin signalling: what's in a chain? - pp571 - 572

Mark Hochstrasser

doi:10.1038/ncb0704-571

When cellular proteins are attached to a Lys 48-linked polyubiquitin chain, the proteasome will usually degrade them. But attaching such a chain to a yeast transcription factor inhibits its activity without degradation, raising questions about how polyubiquitination regulates transcriptional activation and why the protein is spared destruction.

Full Text - Ubiquitin signalling: what's in a chain? | PDF (129 KB) - Ubiquitin signalling: what's in a chain?

See also: Letter by Flick et al.

Uncoiling centriole duplication - pp573 - 575

Bruce Nash & Bruce Bowerman

doi:10.1038/ncb0704-573

The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.

Full Text - Uncoiling centriole duplication | PDF (141 KB) - Uncoiling centriole duplication

Sleeping policemen for DNA replication? - pp576 - 577

Daniel Fisher & Marcel Méchali

doi:10.1038/ncb0704-576

The ATM and ATR protein kinases are important mediators of the cellular response to DNA damage. They regulate multiple cellular functions as part of a stress response programme, including the activation of cell-cycle checkpoints, DNA replication, DNA repair and DNA recombination. A provocative new study suggests that ATM and ATR also regulate normal DNA replication in unperturbed cells.

Full Text - Sleeping policemen for DNA replication? | PDF (143 KB) - Sleeping policemen for DNA replication?

See also: Letter by Shechter et al.

Post-replication repair: ubiquitin throws the switch - p578

Sowmya Swaminathan

doi:10.1038/ncb0704-578

Full Text - Post-replication repair: ubiquitin throws the switch | PDF (104 KB) - Post-replication repair: ubiquitin throws the switch

A nuclear escort for -catenin - pp579 - 580

Nicholas S. Tolwinski & Eric Wieschaus

doi:10.1038/ncb0704-579

Understanding the regulation of -catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for -catenin's nuclear localization, thereby promoting its transcriptional activity.

Full Text - A nuclear escort for -catenin | PDF (266 KB) - A nuclear escort for -catenin

See also: Letter by Townsley et al.

Centrosome migration: until myosin drags us apart - p581

Alison Schuldt

doi:10.1038/ncb0704-581

Full Text - Centrosome migration: until myosin drags us apart | PDF (146 KB) - Centrosome migration: until myosin drags us apart

Genes, history and detail - p582

Peter F. R. Little reviews Molecular Biology of the Gene, Fifth Edition by James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine & Richard Losick

doi:10.1038/ncb0704-582

Full Text - Genes, history and detail | PDF (82 KB) - Genes, history and detail

How science fails women – and men - p583

Virginia Valian reviews Women in Science
Career Processes and Outcomes by Yu Xie & Kimberlee A. Shauman

doi:10.1038/ncb0704-583

Full Text - How science fails women – and men | PDF (85 KB) - How science fails women – and men

Secretory trafficking in neuronal dendrites - pp585 - 591

April C. Horton & Michael D. Ehlers

doi:10.1038/ncb0704-585

Abstract - | Full Text - Secretory trafficking in neuronal dendrites | PDF (945 KB) - Secretory trafficking in neuronal dendrites

Cell of the month: X marks the spot - p593

Matthew Daniels

doi:10.1038/ncb0704-593

Full Text - Cell of the month: X marks the spot | PDF (465 KB) - Cell of the month: X marks the spot

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons - pp595 - 608

Minh Dang Nguyen, Tianzhi Shu, Kamon Sanada, Roxanne C. Larivière, Huang-Chun Tseng, Sang Ki Park, Jean-Pierre Julien & Li-Huei Tsai

doi:10.1038/ncb1139

Abstract - | Full Text - A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons | PDF (1,961 KB) - A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons | Supplementary information

See also: News and Views by Holzbaur

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 - pp609 - 617

Xiaolong Yang, Kuanping Yu, Yawei Hao, Da-ming Li, Rodney Stewart, Karl L. Insogna & Tian Xu

doi:10.1038/ncb1140

Abstract - | Full Text - LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 | PDF (749 KB) - LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 | Supplementary information

Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation - pp618 - 625

Neil Phillips, Richard D. Hayward & Vassilis Koronakis

doi:10.1038/ncb1148

First Paragraph - | Full Text - Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation | PDF (1,099 KB) - Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation | Supplementary information

Pygopus and Legless target Armadillo/-catenin to the nucleus to enable its transcriptional co-activator function - pp626 - 633

Fiona M. Townsley, Adam Cliffe & Mariann Bienz

doi:10.1038/ncb1141

First Paragraph - | Full Text - Pygopus and Legless target Armadillo/-catenin to the nucleus to enable its transcriptional co-activator function | PDF (1,736 KB) - Pygopus and Legless target Armadillo/-catenin to the nucleus to enable its transcriptional co-activator function | Supplementary information

See also: News and Views by Tolwinski & Wieschaus

Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain - pp634 - 641

Karin Flick, Ikram Ouni, James A. Wohlschlegel, Chrissy Capati, W. Hayes McDonald, John R. Yates, 3rd & Peter Kaiser

doi:10.1038/ncb1143

First Paragraph - | Full Text - Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain | PDF (378 KB) - Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain | Supplementary information

See also: News and Views by Hochstrasser

HIF activation by pH-dependent nucleolar sequestration of VHL - pp642 - 647

Karim Mekhail, Lakshman Gunaratnam, Marie-Eve Bonicalzi & Stephen Lee

doi:10.1038/ncb1144

First Paragraph - | Full Text - HIF activation by pH-dependent nucleolar sequestration of VHL | PDF (548 KB) - HIF activation by pH-dependent nucleolar sequestration of VHL | Supplementary information

ATR and ATM regulate the timing of DNA replication origin firing - pp648 - 655

David Shechter, Vincenzo Costanzo & Jean Gautier

doi:10.1038/ncb1145

First Paragraph - | Full Text - ATR and ATM regulate the timing of DNA replication origin firing | PDF (954 KB) - ATR and ATM regulate the timing of DNA replication origin firing | Supplementary information

See also: News and Views by Fisher & Méchali

Centriolar SAS-5 is required for centrosome duplication in C. elegans - pp656 - 664

Marie Delattre, Sebastian Leidel, Khursheed Wani, Karine Baumer, Jeannine Bamat, Heinke Schnabel, Richard Feichtinger, Ralf Schnabel & Pierre Gönczy

doi:10.1038/ncb1146

First Paragraph - | Full Text - Centriolar SAS-5 is required for centrosome duplication in C. elegans | PDF (1,647 KB) - Centriolar SAS-5 is required for centrosome duplication in C. elegans | Supplementary information

PML regulates p53 stability by sequestering Mdm2 to the nucleolus - pp665 - 672

Rosa Bernardi, Pier Paolo Scaglioni, Stephan Bergmann, Henning F. Horn, Karen H. Vousden & Pier Paolo Pandolfi

doi:10.1038/ncb1147

First Paragraph - | Full Text - PML regulates p53 stability by sequestering Mdm2 to the nucleolus | PDF (809 KB) - PML regulates p53 stability by sequestering Mdm2 to the nucleolus | Supplementary information

PTOP interacts with POT1 and regulates its localization to telomeres - pp673 - 680

Dan Liu, Amin Safari, Matthew S O'Connor, Doug W. Chan, Andrew Laegeler, Jun Qin & Zhou Songyang

doi:10.1038/ncb1142

First Paragraph - | Full Text - PTOP interacts with POT1 and regulates its localization to telomeres | PDF (547 KB) - PTOP interacts with POT1 and regulates its localization to telomeres | Supplementary information