Table of contents
July 2004, Volume 6 No 7 pp563-680
About the coverEditorial
Developing Milestones - p563
doi:10.1038/ncb0704-563
Full Text - Developing Milestones | PDF (78 KB) - Developing Milestones
Correspondence
Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 - pp565 - 567
Elzbieta H Wloga, Vittoria Criniti, Roderick T. Bronson & Lili Yamasaki
doi:10.1038/ncb0704-565
Full Text - Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | PDF (149 KB) - Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | Supplementary information
Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 - pp567 - 568
D. E. Brash
doi:10.1038/ncb0704-567
Full Text - Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1 | PDF (149 KB) - Reply: Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1
News and Views
Tangled NUDELs? - pp569 - 570
Erika L. F. Holzbaur
doi:10.1038/ncb0704-569
NUDEL was first identified as a protein required for nuclear migration in filamentous fungi. Now, a study shows that it is important for normal assembly of neurofilaments in the mammalian nervous system. In utero knockdown of NUDEL expression results in disruption of neurofilament organization.
Full Text - Tangled NUDELs? | PDF (113 KB) - Tangled NUDELs?
See also: Article by Nguyen et al.
Ubiquitin signalling: what's in a chain? - pp571 - 572
Mark Hochstrasser
doi:10.1038/ncb0704-571
When cellular proteins are attached to a Lys 48-linked polyubiquitin chain, the proteasome will usually degrade them. But attaching such a chain to a yeast transcription factor inhibits its activity without degradation, raising questions about how polyubiquitination regulates transcriptional activation and why the protein is spared destruction.
Full Text - Ubiquitin signalling: what's in a chain? | PDF (129 KB) - Ubiquitin signalling: what's in a chain?
See also: Letter by Flick et al.
Uncoiling centriole duplication - pp573 - 575
Bruce Nash & Bruce Bowerman
doi:10.1038/ncb0704-573
The invariant duplication of the centriole once per cell cycle is critical for cell division. SAS-5 is the most recent of three coiled-coil centriolar proteins found to be required for centriole duplication in Caenorhabditis elegans.
Full Text - Uncoiling centriole duplication | PDF (141 KB) - Uncoiling centriole duplication
Sleeping policemen for DNA replication? - pp576 - 577
Daniel Fisher & Marcel Méchali
doi:10.1038/ncb0704-576
The ATM and ATR protein kinases are important mediators of the cellular response to DNA damage. They regulate multiple cellular functions as part of a stress response programme, including the activation of cell-cycle checkpoints, DNA replication, DNA repair and DNA recombination. A provocative new study suggests that ATM and ATR also regulate normal DNA replication in unperturbed cells.
Full Text - Sleeping policemen for DNA replication? | PDF (143 KB) - Sleeping policemen for DNA replication?
See also: Letter by Shechter et al.
Post-replication repair: ubiquitin throws the switch - p578
Sowmya Swaminathan
doi:10.1038/ncb0704-578
Full Text - Post-replication repair: ubiquitin throws the switch | PDF (104 KB) - Post-replication repair: ubiquitin throws the switch
A nuclear escort for
-catenin - pp579 - 580
Nicholas S. Tolwinski & Eric Wieschaus
doi:10.1038/ncb0704-579
Understanding the regulation of
-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for
-catenin's nuclear localization, thereby promoting its transcriptional activity.
Full Text - A nuclear escort for
-catenin | PDF (266 KB) - A nuclear escort for
-catenin
See also: Letter by Townsley et al.
Centrosome migration: until myosin drags us apart - p581
Alison Schuldt
doi:10.1038/ncb0704-581
Full Text - Centrosome migration: until myosin drags us apart | PDF (146 KB) - Centrosome migration: until myosin drags us apart
Book Reviews
Genes, history and detail - p582
Peter F. R. Little reviews Molecular Biology of the Gene, Fifth Edition by James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine & Richard Losick
doi:10.1038/ncb0704-582
Full Text - Genes, history and detail | PDF (82 KB) - Genes, history and detail
How science fails women – and men - p583
Virginia Valian reviews Women in Science
Career Processes and Outcomes by Yu Xie
&
Kimberlee A. Shauman
doi:10.1038/ncb0704-583
Full Text - How science fails women – and men | PDF (85 KB) - How science fails women – and men
Review
Secretory trafficking in neuronal dendrites - pp585 - 591
April C. Horton & Michael D. Ehlers
doi:10.1038/ncb0704-585
Abstract - | Full Text - Secretory trafficking in neuronal dendrites | PDF (945 KB) - Secretory trafficking in neuronal dendrites
News and Views
Cell of the month: X marks the spot - p593
Matthew Daniels
doi:10.1038/ncb0704-593
Full Text - Cell of the month: X marks the spot | PDF (465 KB) - Cell of the month: X marks the spot
Articles
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons - pp595 - 608
Minh Dang Nguyen, Tianzhi Shu, Kamon Sanada, Roxanne C. Larivière, Huang-Chun Tseng, Sang Ki Park, Jean-Pierre Julien & Li-Huei Tsai
doi:10.1038/ncb1139
Abstract - | Full Text - A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons | PDF (1,961 KB) - A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons | Supplementary information
See also: News and Views by Holzbaur
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 - pp609 - 617
Xiaolong Yang, Kuanping Yu, Yawei Hao, Da-ming Li, Rodney Stewart, Karl L. Insogna & Tian Xu
doi:10.1038/ncb1140
Abstract - | Full Text - LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 | PDF (749 KB) - LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1 | Supplementary information
Letters
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation - pp618 - 625
Neil Phillips, Richard D. Hayward & Vassilis Koronakis
doi:10.1038/ncb1148
First Paragraph - | Full Text - Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation | PDF (1,099 KB) - Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation | Supplementary information
Pygopus and Legless target Armadillo/
-catenin to the nucleus to enable its transcriptional co-activator function - pp626 - 633
Fiona M. Townsley, Adam Cliffe & Mariann Bienz
doi:10.1038/ncb1141
First Paragraph - | Full Text - Pygopus and Legless target Armadillo/
-catenin to the nucleus to enable its transcriptional co-activator function | PDF (1,736 KB) - Pygopus and Legless target Armadillo/
-catenin to the nucleus to enable its transcriptional co-activator function | Supplementary information
See also: News and Views by Tolwinski & Wieschaus
Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain - pp634 - 641
Karin Flick, Ikram Ouni, James A. Wohlschlegel, Chrissy Capati, W. Hayes McDonald, John R. Yates, 3rd & Peter Kaiser
doi:10.1038/ncb1143
First Paragraph - | Full Text - Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain | PDF (378 KB) - Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain | Supplementary information
See also: News and Views by Hochstrasser
HIF activation by pH-dependent nucleolar sequestration of VHL - pp642 - 647
Karim Mekhail, Lakshman Gunaratnam, Marie-Eve Bonicalzi & Stephen Lee
doi:10.1038/ncb1144
First Paragraph - | Full Text - HIF activation by pH-dependent nucleolar sequestration of VHL | PDF (548 KB) - HIF activation by pH-dependent nucleolar sequestration of VHL | Supplementary information
ATR and ATM regulate the timing of DNA replication origin firing - pp648 - 655
David Shechter, Vincenzo Costanzo & Jean Gautier
doi:10.1038/ncb1145
First Paragraph - | Full Text - ATR and ATM regulate the timing of DNA replication origin firing | PDF (954 KB) - ATR and ATM regulate the timing of DNA replication origin firing | Supplementary information
See also: News and Views by Fisher & Méchali
Centriolar SAS-5 is required for centrosome duplication in C. elegans - pp656 - 664
Marie Delattre, Sebastian Leidel, Khursheed Wani, Karine Baumer, Jeannine Bamat, Heinke Schnabel, Richard Feichtinger, Ralf Schnabel & Pierre Gönczy
doi:10.1038/ncb1146
First Paragraph - | Full Text - Centriolar SAS-5 is required for centrosome duplication in C. elegans | PDF (1,647 KB) - Centriolar SAS-5 is required for centrosome duplication in C. elegans | Supplementary information
PML regulates p53 stability by sequestering Mdm2 to the nucleolus - pp665 - 672
Rosa Bernardi, Pier Paolo Scaglioni, Stephan Bergmann, Henning F. Horn, Karen H. Vousden & Pier Paolo Pandolfi
doi:10.1038/ncb1147
First Paragraph - | Full Text - PML regulates p53 stability by sequestering Mdm2 to the nucleolus | PDF (809 KB) - PML regulates p53 stability by sequestering Mdm2 to the nucleolus | Supplementary information
PTOP interacts with POT1 and regulates its localization to telomeres - pp673 - 680
Dan Liu, Amin Safari, Matthew S O'Connor, Doug W. Chan, Andrew Laegeler, Jun Qin & Zhou Songyang
doi:10.1038/ncb1142
First Paragraph - | Full Text - PTOP interacts with POT1 and regulates its localization to telomeres | PDF (547 KB) - PTOP interacts with POT1 and regulates its localization to telomeres | Supplementary information


