Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Letter
Nature Cell Biology 6, 642–647 (1 July 2004) | doi:10.1038/ncb1144
HIF activation by pH-dependent nucleolar sequestration of VHL
&
Abstract
Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive response to cellular hypoxia is HIF (hypoxia-inducible factor), a transcription factor that activates an array of genes implicated in oxygen homeostasis, tumour vascularization and ischaemic preconditioning.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
