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Letter

Nature Cell Biology 6, 634–641 (1 July 2004) | doi:10.1038/ncb1143

Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain

Karin Flick , Ikram Ouni , James A. Wohlschlegel , Chrissy Capati , W. Hayes McDonald , John R. Yates & Peter Kaiser

The ubiquitin ligase SCFMet30 is required for cell cycle progression in budding yeast. The critical function of SCFMet30 is inactivation of the transcriptional activator Met4.