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Letter
Nature Cell Biology 6, 626–633 (1 July 2004) | doi:10.1038/ncb1141
Pygopus and Legless target Armadillo/|[beta]|-catenin to the nucleus to enable its transcriptional co-activator function
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Abstract
Wnt signalling controls the transcription of genes that function during normal and malignant development. Stimulation by canonical Wnt ligands activates β-catenin (or Drosophila melanogaster Armadillo) by blocking its phosphorylation, resulting in its stabilization and translocation to the nucleus.
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