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Nature Cell Biology  6, 579 - 580 (2004)
doi:10.1038/ncb0704-579

A nuclear escort for bold beta-catenin

Nicholas S. Tolwinski & Eric Wieschaus

Nicholas S. Tolwinski and Eric Wieschaus are at the Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. ewieschaus@molbio.princeton.edu

Understanding the regulation of beta-catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for beta-catenin's nuclear localization, thereby promoting its transcriptional activity.

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Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
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