1. Nicholas S. Tolwinski and Eric Wieschaus are at the Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. e-mail: ewieschaus@molbio.princeton.edu

Abstract

Understanding the regulation of -catenin, a key component of the Wnt signalling pathway, has important implications for developmental processes, maintenance of stem cells and the formation of many cancers. The latest report suggests that a nuclear complex consisting of Pygopus and Legless is required for -catenin's nuclear localization, thereby promoting its transcriptional activity.

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