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Membrane Traffic
June 2004 Contents Archive Feedback

This month, a special Nature Cell Biology issue on Membrane Traffic casts a spotlight on this dynamic and evolving area of cell biology with a series of specially commissioned Reviews, Perspectives, Commentaries and News & Views articles.

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Editorial

Focus on Membrane Traffic

Spotlight on membrane traffic p467

doi:10.1038/ncb0604-467


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Commentary

Focus on Membrane Traffic

Organelle identity and the organization of membrane traffic pp469 - 472

Sean Munro

doi:10.1038/ncb0604-469

Generating and maintaining features that distinguish one organelle from another is essential for accurate membrane traffic. Recent work has revealed that organelles express 'identity' by the local generation of activated GTP-binding proteins and lipid species. These recruiting determinants are then recognized by cytosolic proteins that facilitate the formation and delivery of vesicles at the correct compartment.


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News and Views

Cdc14 phosphatase resolves the rDNA segregation delay pp473 - 475

Gislene Pereira & Elmar Schiebel

doi:10.1038/ncb0604-473

Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.


Focus on Membrane Traffic

Fusion has found its calcium sensor pp476 - 478

Jacopo Meldolesi & Evelina Chieregatti

doi:10.1038/ncb0604-476

Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.


Focus on Membrane Traffic

Tip-ping off the COPs p478

Jon Reynolds

doi:10.1038/ncb0604-478


Hsp90 invades the outside pp479 - 480

Didier Picard

doi:10.1038/ncb0604-479

Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.


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Book Review

Focus on Membrane Traffic

Greasy attractions p481

Shamshad Cockcroft reviews Phosphoinositides in Subcellular Targeting and Enzyme Activation by Harald Stenmark

doi:10.1038/ncb0604-481


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Historical Perspective

Focus on Membrane Traffic

Merging cultures in the study of membrane traffic pp483 - 486

Randy Schekman

doi:10.1038/ncb0604-483


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Review

Focus on Membrane Traffic

PI-loting membrane traffic pp487 - 492

Maria Antonietta De Matteis & Anna Godi

doi:10.1038/ncb0604-487


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Meeting Report

Focus on Membrane Traffic

Mediterranean views on epithelial polarity pp493 - 496

Barbara Janssens & Philippe Chavrier

doi:10.1038/ncb0604-493


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News and Views

Cell of the month: Nuclear pore complexes in yeast p497

Elena Kiseleva

doi:10.1038/ncb0604-497


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Articles

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II pp499 - 506

Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita & Issei Komuro

doi:10.1038/ncb1137


Functional proteomic screens reveal an essential extracellular role for hsp90alpha in cancer cell invasiveness pp507 - 514

Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan W. Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag & Daniel G. Jay

doi:10.1038/ncb1131


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Letters

Memo mediates ErbB2-driven cell motility pp515 - 522

Romina Marone, Daniel Hess, David Dankort, William J. Muller, Nancy E. Hynes & Ali Badache

doi:10.1038/ncb1134


Myosin-X provides a motor-based link between integrins and the cytoskeleton pp523 - 531

Hongquan Zhang, Jonathan S. Berg, Zhilun Li, Yunling Wang, Pernilla Lång, Aurea D. Sousa, Aparna Bhaskar, Richard E. Cheney & Staffan Strömblad

doi:10.1038/ncb1136


Hematopoietic stem cells convert into liver cells within days without fusion pp532 - 539

Yoon-Young Jang, Michael I. Collector, Stephen B. Baylin, Anna Mae Diehl & Saul J. Sharkis

doi:10.1038/ncb1132


The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila pp540 - 546

Svetlana Cvejic, Zheng Zhu, Sarah J. Felice, Yemiliya Berman & Xin-Yun Huang

doi:10.1038/ncb1133


Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling pp547 - 554

Sachiko Kamakura, Koji Oishi, Takeshi Yoshimatsu, Masato Nakafuku, Norihisa Masuyama & Yukiko Gotoh

doi:10.1038/ncb1138


Cohesin SMC1beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination pp555 - 562

Ekaterina Revenkova, Maureen Eijpe, Christa Heyting, Craig A. Hodges, Patricia A. Hunt, Bodo Liebe, Harry Scherthan & Rolf Jessberger

doi:10.1038/ncb1135


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