Focus on Membrane Traffic

Spotlight on membrane traffic - p467

doi:10.1038/ncb0604-467

Full Text - Spotlight on membrane traffic | PDF (142 KB) - Spotlight on membrane traffic

Focus on Membrane Traffic

Organelle identity and the organization of membrane traffic - pp469 - 472

Sean Munro

doi:10.1038/ncb0604-469

Generating and maintaining features that distinguish one organelle from another is essential for accurate membrane traffic. Recent work has revealed that organelles express 'identity' by the local generation of activated GTP-binding proteins and lipid species. These recruiting determinants are then recognized by cytosolic proteins that facilitate the formation and delivery of vesicles at the correct compartment.

Full Text - Organelle identity and the organization of membrane traffic | PDF (115 KB) - Organelle identity and the organization of membrane traffic

Cdc14 phosphatase resolves the rDNA segregation delay - pp473 - 475

Gislene Pereira & Elmar Schiebel

doi:10.1038/ncb0604-473

Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.

Full Text - Cdc14 phosphatase resolves the rDNA segregation delay | PDF (105 KB) - Cdc14 phosphatase resolves the rDNA segregation delay

Focus on Membrane Traffic

Fusion has found its calcium sensor - pp476 - 478

Jacopo Meldolesi & Evelina Chieregatti

doi:10.1038/ncb0604-476

Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.

Full Text - Fusion has found its calcium sensor | PDF (215 KB) - Fusion has found its calcium sensor

Focus on Membrane Traffic

Tip-ping off the COPs - p478

Jon Reynolds

doi:10.1038/ncb0604-478

Full Text - Tip-ping off the COPs | PDF (158 KB) - Tip-ping off the COPs

Hsp90 invades the outside - pp479 - 480

Didier Picard

doi:10.1038/ncb0604-479

Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.

Full Text - Hsp90 invades the outside | PDF (130 KB) - Hsp90 invades the outside

Focus on Membrane Traffic

Greasy attractions - p481

Shamshad Cockcroft reviews Phosphoinositides in Subcellular Targeting and Enzyme Activation by Harald Stenmark

doi:10.1038/ncb0604-481

Full Text - Greasy attractions | PDF (89 KB) - Greasy attractions

Focus on Membrane Traffic

Merging cultures in the study of membrane traffic - pp483 - 486

Randy Schekman

doi:10.1038/ncb0604-483

Abstract - | Full Text - Merging cultures in the study of membrane traffic | PDF (193 KB) - Merging cultures in the study of membrane traffic

Focus on Membrane Traffic

PI-loting membrane traffic - pp487 - 492

Maria Antonietta De Matteis & Anna Godi

doi:10.1038/ncb0604-487

Abstract - | Full Text - PI-loting membrane traffic | PDF (163 KB) - PI-loting membrane traffic

Focus on Membrane Traffic

Mediterranean views on epithelial polarity - pp493 - 496

Barbara Janssens & Philippe Chavrier

doi:10.1038/ncb0604-493

Abstract - | Full Text - Mediterranean views on epithelial polarity | PDF (545 KB) - Mediterranean views on epithelial polarity

Cell of the month: Nuclear pore complexes in yeast - p497

Elena Kiseleva

doi:10.1038/ncb0604-497

Full Text - Cell of the month: Nuclear pore complexes in yeast | PDF (334 KB) - Cell of the month: Nuclear pore complexes in yeast

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II - pp499 - 506

Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita & Issei Komuro

doi:10.1038/ncb1137

Abstract - | Full Text - Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II | PDF (2,273 KB) - Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II | Supplementary information

Functional proteomic screens reveal an essential extracellular role for hsp90 in cancer cell invasiveness - pp507 - 514

Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan W. Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag & Daniel G. Jay

doi:10.1038/ncb1131

Abstract - | Full Text - Functional proteomic screens reveal an essential extracellular role for hsp90 in cancer cell invasiveness | PDF (303 KB) - Functional proteomic screens reveal an essential extracellular role for hsp90 in cancer cell invasiveness | Supplementary information

Memo mediates ErbB2-driven cell motility - pp515 - 522

Romina Marone, Daniel Hess, David Dankort, William J. Muller, Nancy E. Hynes & Ali Badache

doi:10.1038/ncb1134

First Paragraph - | Full Text - Memo mediates ErbB2-driven cell motility | PDF (417 KB) - Memo mediates ErbB2-driven cell motility | Supplementary information

Myosin-X provides a motor-based link between integrins and the cytoskeleton - pp523 - 531

Hongquan Zhang, Jonathan S. Berg, Zhilun Li, Yunling Wang, Pernilla Lång, Aurea D. Sousa, Aparna Bhaskar, Richard E. Cheney & Staffan Strömblad

doi:10.1038/ncb1136

First Paragraph - | Full Text - Myosin-X provides a motor-based link between integrins and the cytoskeleton | PDF (836 KB) - Myosin-X provides a motor-based link between integrins and the cytoskeleton | Supplementary information

Hematopoietic stem cells convert into liver cells within days without fusion - pp532 - 539

Yoon-Young Jang, Michael I. Collector, Stephen B. Baylin, Anna Mae Diehl & Saul J. Sharkis

doi:10.1038/ncb1132

First Paragraph - | Full Text - Hematopoietic stem cells convert into liver cells within days without fusion | PDF (919 KB) - Hematopoietic stem cells convert into liver cells within days without fusion | Supplementary information

The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila - pp540 - 546

Svetlana Cvejic, Zheng Zhu, Sarah J. Felice, Yemiliya Berman & Xin-Yun Huang

doi:10.1038/ncb1133

First Paragraph - | Full Text - The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila | PDF (269 KB) - The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila

Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling - pp547 - 554

Sachiko Kamakura, Koji Oishi, Takeshi Yoshimatsu, Masato Nakafuku, Norihisa Masuyama & Yukiko Gotoh

doi:10.1038/ncb1138

First Paragraph - | Full Text - Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling | PDF (399 KB) - Hes binding to STAT3 mediates crosstalk between Notch and JAK–STAT signalling | Supplementary information

Cohesin SMC1 is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination - pp555 - 562

Ekaterina Revenkova, Maureen Eijpe, Christa Heyting, Craig A. Hodges, Patricia A. Hunt, Bodo Liebe, Harry Scherthan & Rolf Jessberger

doi:10.1038/ncb1135

First Paragraph - | Full Text - Cohesin SMC1 is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination | PDF (1,006 KB) - Cohesin SMC1 is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination | Supplementary information