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Letter
Nature Cell Biology 6, 547–554 (1 June 2004) | doi:10.1038/ncb1138
Hes binding to STAT3 mediates crosstalk between Notch and JAK|[ndash]|STAT signalling
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Abstract
Although the Notch and JAK–STAT signalling pathways fulfill overlapping roles in growth and differentiation regulation, no coordination mechanism has been proposed to explain their relationship. Here we show that STAT3 is activated in the presence of active Notch, as well as the Notch effectors Hes1 and Hes5. Hes proteins associate with JAK2 and STAT3, and facilitate complex formation between JAK2 and STAT3, thus promoting STAT3 phosphorylation and activation.
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