Randy Schekman is in the Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California 94720-3202, USA. schekman@uclink4.berkeley.edu
Membrane and organelle assembly has emerged as a dominant theme in cell biology of the twenty-first century. Current approaches and questions have been formulated as a result of numerous historical threads that together weave a complex picture of cellular compartments. The confluence of morphologic, genetic and biochemical approaches laid the foundations for study in this area, and they continue to strengthen our understanding of this essential aspect of cell structure and function.
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