Jacopo Meldolesi is in the Department of Neuroscience, Vita-Salute San Raffaele University, Center of Excellence in Cellular Pathophysiology. Evelina Chieregatti is in the Scientific Institute San Raffaele, DIBIT, Via Olgettina 58, 20132 Milan Italy. meldolesi.Jacopo@hsr.it
Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.
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