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Letter
Nature Cell Biology 6, 420–426 (1 May 2004) | doi:10.1038/ncb1125
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
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Abstract
Polarized cell movement is triggered by the development of a PtdIns(3,4,5)P3 gradient at the membrane, which is followed by rearrangement of the actin cytoskeleton. The WASP family verprolin homologous protein (WAVE) is essential for lamellipodium formation at the leading edge by activating the Arp2/3 complex downstream of Rac GTPase.
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