Phillip R. Gordon-Weeks is in the MRC Centre for Developmental Neurobiology, King's College London, London, UK.
The microtubule-associated proteins MAP2 and tau are important for regulating microtubule dynamics and bundling, but can also bind to actin filaments. It seems, however, that only MAP2 can bind directly to actin filaments and, curiously, the actin-binding domain is situated within the microtubule-binding domain.
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