1. Jean-Luc Perfettini and Guido Kroemer are at the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, F-94805 Villejuif, France.
2. Romano T. Kroemer is at Molecular Modeling and Design, Pharmacia, Viale Pasteur 10, Nerviano (MI) 20014, Italy. e-mail: kroemer@igr.fr

Abstract

p53 can induce apoptosis through its well defined role as a regulator of transcription, but also by a less well defined transcription-independent mechanism. Two recent studies demonstrate that p53 mediates mitochondrial permeabilization through direct physical interactions with the pro-apoptotic Bcl-2 family members, Bax and Bak.

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