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Letter
Nature Cell Biology 6, 351–357 (1 April 2004) | doi:10.1038/ncb1111
SREBPs suppress IRS-2-mediated insulin signalling in the liver
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Abstract
Insulin receptor substrate 2 (IRS-2) is the main mediator of insulin signalling in the liver, controlling insulin sensitivity. Sterol regulatory element binding proteins (SREBPs) have been established as transcriptional regulators of lipid synthesis.
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