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Nature Cell Biology 6, 282–284 (1 April 2004) | doi:10.1038/ncb0404-282

Unravelling protein sorting

W. James Nelson & Enrique Rodriguez-Boulan

Many cell types display an asymmetric or polarized organization of proteins in different domains of the plasma membrane. This organization reflects a requirement for asymmetric growth or division, directional migration, or vectorial transport and delivery of solutes/signals.