News and Views
Nature Cell Biology 6, 290 - 292 (2004)
doi:10.1038/ncb0404-290
Understanding the diversity of prions
Adriano Aguzzi1
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Adriano Aguzzi is in the Universitäts Spital Zürich, Institut für Neuropathologie, Schmelzbergstr. 12, CH-8091 Zürich, Switzerland.
e-mail: adriano@pathol.unizh.ch
Abstract
The protein-only hypothesis proposes that prions propagate by imparting specific folds onto cellular proteins. This hypothesis has met with resistance, partly because of the observation that many phenotypically distinct prion 'strains' are known to exist in yeast and mammals. Recent work on yeast prions may help reconcile the occurrence of prion strains with the prion hypothesis.
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