1. David Dominguez-Sola and Riccardo Dalla-Favera are in the Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
   e-mail: rd10@columbia.edu

Abstract

The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.

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