News and Views
Nature Cell Biology 6, 288 - 289 (2004)
doi:10.1038/ncb0404-288
PINning down the c-Myc oncoprotein
David Dominguez-Sola1 & Riccardo Dalla-Favera1
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David Dominguez-Sola and Riccardo Dalla-Favera are in the Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
e-mail: rd10@columbia.edu
Abstract
The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.
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