News and Views
Nature Cell Biology 6, 282 - 284 (2004)
doi:10.1038/ncb0404-282
Unravelling protein sorting
W. James Nelson1 & Enrique Rodriguez-Boulan2
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W. James Nelson is in the Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305-5435, USA.
e-mail: wjnelson@stanford.edu -
Enrique Rodriguez-Boulan is in the Margaret M. Dyson Vision Research Institute, Weill Medical College of Cornell University, New York, NY 10021, USA.
e-mail: boulan@med.cornell.edu
Abstract
Protein sorting to distinct plasma membrane domains in polarized epithelial cells is thought to occur in the Golgi complex, and to be mediated in part by lipid rafts. Now, analysis of protein trafficking in live cells has revealed unexpected sorting pathways that raise new questions about the specificity and sites of action of sorting mechanisms.
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