1. Simone L. Blagg and Robert H. Insall are in the School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
   e-mail: r.h.insall@bham.ac.uk

Abstract

SCAR/WAVE proteins are central regulators of cell motility that coordinate actin reorganization through activation of the Arp2/3 complex. Their activity is controlled by a large complex with four other members. A new study contradicts earlier work by suggesting that the entire complex is required for SCAR/WAVE activity at the leading edge.

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