Table of contents
March 2004, Volume 6 No 3 pp171-274
About the coverBook Review
Science, Society and the Nobel Prize - p173
Andreas Trumpp & Daniel Kalman review How to win the Nobel Prize. An Unexpected Life in Science by J. Michael Bishop
doi:10.1038/ncb0304-173
Full Text - Science, Society and the Nobel Prize | PDF (94 KB) - Science, Society and the Nobel Prize
News and Views
GGAing ubiquitin to the endosome - pp175 - 177
Markus Babst
doi:10.1038/ncb0304-175
Delivery of transmembrane proteins to the lumen of the lysosome is mediated by their ubiquitination, and subsequent recognition and sorting at the endosome. A new group of ubiquitin-binding proteins has now been identified that seem to function in the delivery of ubiquitinated cargo both from the cell surface and the trans-Golgi network (TGN) to the lysosome.
Full Text - GGAing ubiquitin to the endosome | PDF (146 KB) - GGAing ubiquitin to the endosome
See also: Letter by Puertollano & Bonifacino | Letter by Scott et al.
Robbing from the pore - pp177 - 179
Benjamin L. Timney & Michael P. Rout
doi:10.1038/ncb0304-177
How do you build a sorting machine that can function with less than half of its sorting components? This problem challenges our understanding of nucleocytoplasmic transport after the finding that yeast can survive with nuclear pore complexes (NPCs) containing only half their original mass of transport-factor-binding domains.
Full Text - Robbing from the pore | PDF (390 KB) - Robbing from the pore
To cluster or not to cluster: FRETting over rafts - pp180 - 181
Susan K. Pierce
doi:10.1038/ncb0304-180
Lipid rafts are thought to be important for signalling cascades by compartmentalizing signalling components in the membrane. This view has recently come under fire because the common method used for isolation of rafts — detergent extraction — is fraught with artefacts. A variety of techniques, including FRET, have been used recently to investigate rafts in their native environment in intact cells. Now, FRET analysis provides evidence that rafts may not have a role in T-cell activation after all.
Full Text - To cluster or not to cluster: FRETting over rafts | PDF (143 KB) - To cluster or not to cluster: FRETting over rafts
Correcting SYNful attachments - pp181 - 183
Sue Biggins
doi:10.1038/ncb0304-181
The remarkable fidelity of chromosome segregation during mitosis and meiosis is critical for preventing birth defects and diseases. The Aurora protein kinases prevent defects in segregation by correcting mistakes in chromosome attachment to the spindle before cells divide.
Full Text - Correcting SYNful attachments | PDF (136 KB) - Correcting SYNful attachments
Resolving a Holliday romance - p184
Jon Reynolds
doi:10.1038/ncb0304-184a
Full Text - Resolving a Holliday romance | PDF (144 KB) - Resolving a Holliday romance
Translating prions at the synapse - pp184 - 187
Jonathan M. Levenson & J. David Sweatt
doi:10.1038/ncb0304-184b
New studies indicate that an Aplysia californica variant of the translational regulator CPEB exhibits prion-like properties, enabling the protein to establish a stable, self-perpetuating and synapse-specific enhancement of neurotransmission. These studies suggest that a radically new kind of signalling — an autocatalytic change in protein conformation — is involved in maintaining long-term memories.
Full Text - Translating prions at the synapse | PDF (326 KB) - Translating prions at the synapse
A SNAP decision in neural cell fate - p187
Donald Mcdonald
doi:10.1038/ncb0304-187
Full Text - A SNAP decision in neural cell fate | PDF (217 KB) - A SNAP decision in neural cell fate
Cell of the month: A dendritic cell sensing a lymphocyte - p188
Olivier Schwartz
doi:10.1038/ncb0304-188
Full Text - Cell of the month: A dendritic cell sensing a lymphocyte | PDF (258 KB) - Cell of the month: A dendritic cell sensing a lymphocyte
Technical Report
Transduction peptides: from technology to physiology - pp189 - 196
Alain Joliot & Alain Prochiantz
doi:10.1038/ncb0304-189
Abstract - | Full Text - Transduction peptides: from technology to physiology | PDF (438 KB) - Transduction peptides: from technology to physiology
Articles
Minimal nuclear pore complexes define FG repeat domains essential for transport - pp197 - 206
Lisa A. Strawn, Tianxiang Shen, Nataliya Shulga, David S. Goldfarb & Susan R. Wente
doi:10.1038/ncb1097
Abstract - | Full Text - Minimal nuclear pore complexes define FG repeat domains essential for transport | PDF (5,462 KB) - Minimal nuclear pore complexes define FG repeat domains essential for transport | Supplementary information
See also: News and Views by Timney & Rout
Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis - pp207 - 214
Klaus-Peter Knoch, Hendrik Bergert, Barbara Borgonovo, Hans-Detlev Saeger, Anke Altkrüger, Paul Verkade & Michele Solimena
doi:10.1038/ncb1099
Abstract - | Full Text - Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis | PDF (671 KB) - Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis | Supplementary information
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence - pp215 - 226
Teiji Wada, Nicholas Joza, Hai-ying M. Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin Schreiber, Erwin F. Wagner, Hiroshi Nishina & Josef M. Penninger
doi:10.1038/ncb1098
Abstract - | Full Text - MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence | PDF (650 KB) - MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence | Supplementary information
Letters
Kinetochore fibre dynamics outside the context of the spindle during anaphase - pp227 - 231
Wei Chen & Dahong Zhang
doi:10.1038/ncb1104
First Paragraph - | Full Text - Kinetochore fibre dynamics outside the context of the spindle during anaphase | PDF (749 KB) - Kinetochore fibre dynamics outside the context of the spindle during anaphase | Supplementary information
Correcting improper chromosome–spindle attachments during cell division - pp232 - 237
Michael A. Lampson, Kishore Renduchitala, Alexey Khodjakov & Tarun M. Kapoor
doi:10.1038/ncb1102
First Paragraph - | Full Text - Correcting improper chromosome–spindle attachments during cell division | PDF (1,288 KB) - Correcting improper chromosome–spindle attachments during cell division | Supplementary information
See also: News and Views by Biggins
Lipid raft proteins have a random distribution during localized activation of the T-cell receptor - pp238 - 243
Oleg O. Glebov & Benjamin J. Nichols
doi:10.1038/ncb1103
First Paragraph - | Full Text - Lipid raft proteins have a random distribution during localized activation of the T-cell receptor | PDF (958 KB) - Lipid raft proteins have a random distribution during localized activation of the T-cell receptor | Supplementary information
See also: News and Views by Pierce
Interactions of GGA3 with the ubiquitin sorting machinery - pp244 - 251
Rosa Puertollano & Juan S. Bonifacino
doi:10.1038/ncb1106
First Paragraph - | Full Text - Interactions of GGA3 with the ubiquitin sorting machinery | PDF (1,620 KB) - Interactions of GGA3 with the ubiquitin sorting machinery | Supplementary information
See also: News and Views by Babst
GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network - pp252 - 259
Patricia M. Scott, Patricia S. Bilodeau, Olga Zhdankina, Stanley C. Winistorfer, Melissa J. Hauglund, Margaret M. Allaman, William R. Kearney, Andrew D. Robertson, Annette L. Boman & Robert C. Piper
doi:10.1038/ncb1107
First Paragraph - | Full Text - GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network | PDF (1,112 KB) - GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network | Supplementary information
See also: News and Views by Babst
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination - pp260 - 267
Anatoliy Li & J. Julian Blow
doi:10.1038/ncb1100
First Paragraph - | Full Text - Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination | PDF (306 KB) - Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination
Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation - pp268 - 274
Patrizia Sini, Angela Cannas, Anthony J. Koleske, Pier Paolo Di Fiore & Giorgio Scita
doi:10.1038/ncb1096
First Paragraph - | Full Text - Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation | PDF (889 KB) - Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation | Supplementary information
