Markus Babst is in the Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
babst@biology.utah.edu
Delivery of transmembrane proteins to the lumen of the lysosome is mediated by their ubiquitination, and subsequent recognition and sorting at the endosome. A new group of ubiquitin-binding proteins has now been identified that seem to function in the delivery of ubiquitinated cargo both from the cell surface and the trans-Golgi network (TGN) to the lysosome.
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