Scaling cell biology: all systems go! - p79

doi:10.1038/ncb0204-79

Full Text - Scaling cell biology: all systems go! | PDF (153 KB) - Scaling cell biology: all systems go!

The Golgi in plants and animals - p81

Akihiko Nakano reviews The Golgi Apparatus and the Plant Secretory Pathway by David Robinson

doi:10.1038/ncb0204-81

Full Text - The Golgi in plants and animals | PDF (81 KB) - The Golgi in plants and animals

Nuclear transport erupts on the slopes of Mount Etna - pp82 - 86

Maureen A. Powers & Mary Dasso

doi:10.1038/ncb0204-82

Abstract - Nuclear transport erupts on the slopes of Mount Etna | Full Text - Nuclear transport erupts on the slopes of Mount Etna | PDF (330 KB) - Nuclear transport erupts on the slopes of Mount Etna

Keeping cartographers busy - pp87 - 89

Matthew S. Hayden & Sankar Ghosh

doi:10.1038/ncb0204-87

In the post-genome era, there is increasing interest in developing quantitative models of cell function at the molecular level. Although data describing the role of individual proteins in cell behaviour remain rate-limiting for such efforts, large-scale screening approaches are providing results that can be used to map the protein–protein interactions of a living biological system.

Full Text - Keeping cartographers busy | PDF (157 KB) - Keeping cartographers busy

Modifiying NEMO - pp89 - 91

Ronald T. Hay

doi:10.1038/ncb0204-89

Genotoxic stress induces a survival response by releasing the transcription factor NF-B from its inhibitor IB. In response to DNA damage, this initially requires the nuclear modification of the IB kinase regulator NEMO/IKK by SUMO and ubiquitin.

Full Text - Modifiying NEMO | PDF (176 KB) - Modifiying NEMO

Security measures at the nuclear pore - p91

Alison Schuldt

doi:10.1038/ncb0204-91

Full Text - Security measures at the nuclear pore | PDF (110 KB) - Security measures at the nuclear pore

The heat is on with TAC1 - pp92 - 93

Tilman Sanchez-Elsner & Frank Sauer

doi:10.1038/ncb0204-92

Specific gene expression patterns must be tightly regulated for eukaryotic cells to acquire unique structural and functional features. A key step is transcriptional initiation, during which epigenetic activators are thought to facilitate the process by establishing and maintaining transcription-competent chromatin structures. Accumulating evidence shows that an epigenetic regulator can also control the next step — transcriptional elongation.

Full Text - The heat is on with TAC1 | PDF (289 KB) - The heat is on with TAC1

Kinetochore sub-structure comes to MIND - pp94 - 95

Vivien Measday & Philip Hieter

doi:10.1038/ncb0204-94

The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a supramolecular complex containing more than 65 proteins that surpasses the size of a ribosome. From within this complex web, stable protein sub-complexes have been extracted, revealing the building blocks for kinetochore assembly.

Full Text - Kinetochore sub-structure comes to MIND | PDF (137 KB) - Kinetochore sub-structure comes to MIND

Cell of the month: An outer hair cell of the inner ear - p96

Mei Zhang & Patrick J. Antonelli

doi:10.1038/ncb0204-96

Full Text - Cell of the month: An outer hair cell of the inner ear | PDF (141 KB) - Cell of the month: An outer hair cell of the inner ear

A physical and functional map of the human TNF-/NF-B signal transduction pathway - pp97 - 105

Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, Pierre-Olivier Angrand, Giovanna Bergamini, Karen Croughton, Cristina Cruciat, Dirk Eberhard, Julien Gagneur, Sonja Ghidelli, Carsten Hopf, Bettina Huhse, Raffaella Mangano, Anne-Marie Michon, Markus Schirle, Judith Schlegl, Markus Schwab, Martin A. Stein, Andreas Bauer, Georg Casari, Gerard Drewes, Anne-Claude Gavin, David B. Jackson, Gerard Joberty, Gitte Neubauer, Jens Rick, Bernhard Kuster & Giulio Superti-Furga

doi:10.1038/ncb1086

Abstract - A physical and functional map of the human TNF-[alpha]/NF-[kappa]B signal transduction pathway | Full Text - A physical and functional map of the human TNF-/NF-B signal transduction pathway | PDF (973 KB) - A physical and functional map of the human TNF-/NF-B signal transduction pathway | Supplementary information

See also: News and Views by Hayden & Ghosh

ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway - pp121 - 128

Takao Ohtsuka, Hoon Ryu, Yohji A. Minamishima, Salvador Macip, Junji Sagara, Keiichi I. Nakayama, Stuart A. Aaronson & Sam W. Lee

doi:10.1038/ncb1087

First Paragraph - ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway | Full Text - ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway | PDF (683 KB) - ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway | Supplementary information

Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex - pp162 - 167

Sheryl T. Smith, Svetlana Petruk, Yurii Sedkov, Elizabeth Cho, Sergei Tillib, Eli Canaani & Alexander Mazo

doi:10.1038/ncb1088

First Paragraph - Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex | Full Text - Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex | PDF (442 KB) - Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex

See also: News and Views by Sanchez-Elsner & Sauer

A novel mechanism for the store-operated calcium influx pathway - pp113 - 120

Tarik Smani, Sergey I. Zakharov, Peter Csutora, Endri Leno, Elena S. Trepakova & Victoria M. Bolotina

doi:10.1038/ncb1089

First Paragraph - A novel mechanism for the store-operated calcium influx pathway | Full Text - A novel mechanism for the store-operated calcium influx pathway | PDF (388 KB) - A novel mechanism for the store-operated calcium influx pathway | Supplementary information

Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network - pp106 - 112

Charles Yeaman, M. Inmaculada Ayala, Jessica R. Wright, Frederic Bard, Carine Bossard, Agnes Ang, Yusuke Maeda, Thomas Seufferlein, Ira Mellman, W. James Nelson & Vivek Malhotra

doi:10.1038/ncb1090

First Paragraph - Protein kinase D regulates basolateral membrane protein exit from : trans: -Golgi network | Full Text - Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network | PDF (637 KB) - Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex - pp129 - 137

Min Sup Song, Su Jeong Song, Nagi G. Ayad, Jin Sook Chang, Joo Hyun Lee, Hyun Kyung Hong, Ho Lee, Naeyun Choi, Jhingook Kim, Hojoong Kim, Jin Woo Kim, Eui-Ju Choi, Marc W. Kirschner & Dae-Sik Lim

doi:10.1038/ncb1091

First Paragraph - The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex | Full Text - The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex | PDF (882 KB) - The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex | Supplementary information

The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression - pp138 - 145

Jennifer S. Searle, Kaila L. Schollaert, Benjamin J. Wilkins & Yolanda Sanchez

doi:10.1038/ncb1092

First Paragraph - The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression | Full Text - The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression | PDF (2,177 KB) - The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression | Supplementary information

Gadd45 mediates the NF-B suppression of JNK signalling by targeting MKK7/JNKK2 - pp146 - 153

Salvatore Papa, Francesca Zazzeroni, Concetta Bubici, Shanthi Jayawardena, Kellean Alvarez, Shuji Matsuda, Dung U. Nguyen, Can G. Pham, Andreas H. Nelsbach, Tiziana Melis, Enrico De Smaele, Wei-Jen Tang, Luciano D'Adamio & Guido Franzoso

doi:10.1038/ncb1093

First Paragraph - Gadd45[beta] mediates the NF-[kappa]B suppression of JNK signalling by targeting MKK7/JNKK2 | Full Text - Gadd45 mediates the NF-B suppression of JNK signalling by targeting MKK7/JNKK2 | PDF (816 KB) - Gadd45 mediates the NF-B suppression of JNK signalling by targeting MKK7/JNKK2 | Supplementary information

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly - pp154 - 161

Donna J. Webb, Karen Donais, Leanna A. Whitmore, Sheila M. Thomas, Christopher E. Turner, J. Thomas Parsons & Alan F. Horwitz

doi:10.1038/ncb1094

First Paragraph - FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly | Full Text - FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly | PDF (456 KB) - FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly | Supplementary information

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks - pp168 - 170

Olga A. Sedelnikova, Izumi Horikawa, Drazen B. Zimonjic, Nicholas C. Popescu, William M. Bonner & J. Carl Barrett

doi:10.1038/ncb1095

Abstract - Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks | Full Text - Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks | PDF (458 KB) - Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks | Supplementary information