1. Ronald T. Hay is at the Biomolecular Sciences Building, School of Biology, University of St Andrews, The North Haugh, St Andrews, KY16 9ST, Scotland.
   e-mail: rth@st-and.ac.uk

Abstract

Genotoxic stress induces a survival response by releasing the transcription factor NF-B from its inhibitor IB. In response to DNA damage, this initially requires the nuclear modification of the IB kinase regulator NEMO/IKK by SUMO and ubiquitin.

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