Cloning around - p1145

doi:10.1038/ncb1204-1145

Full Text - Cloning around | PDF (90 KB) - Cloning around

There goes the neighbourhood: Eps8 joins the barbed-end crowd - pp1147 - 1149

Henry N. Higgs

doi:10.1038/ncb1204-1147

The finding that Eps8 caps the barbed ends of actin filaments adds to the growing list of factors responsible for controlling the dynamics of actin polymerization. The requirements for these capping proteins may vary in each cellular context, but EPS-8 seems to be critical during intestinal morphogenesis in the worm.

Full Text - There goes the neighbourhood: Eps8 joins the barbed-end crowd | PDF (266 KB) - There goes the neighbourhood: Eps8 joins the barbed-end crowd

See also: Letter by Croce et al. | Letter by Disanza et al.

PINOID pinpoints auxin - p1149

Myrto Raftopoulou

doi:10.1038/ncb1204-1149

Full Text - PINOID pinpoints auxin | PDF (164 KB) - PINOID pinpoints auxin

Tudor domains track down DNA breaks - pp1150 - 1152

Manuel Stucki & Stephen P. Jackson

doi:10.1038/ncb1204-1150

How do cells track down the occasional lesion among the billons of base pairs of chromosomal DNA? A surprising discovery unravels a potential new mechanism: the Tudor domains of the DNA-damage response factor 53BP1 interact with methylated histones that are likely to become exposed during local chromatin relaxation at sites of DNA double-strand breaks.

Full Text - Tudor domains track down DNA breaks | PDF (181 KB) - Tudor domains track down DNA breaks

A second RING to destroy p27^Kip1 - pp1153 - 1155

Ludger Hengst

doi:10.1038/ncb1204-1153

The cell cycle regulator p27^Kip1 must be degraded to permit cell division. Degradation is moderate in G1 phase, but is enhanced in S-phase. Now, a novel ubiquitin ligase that can ubiquitinate p27 leading to its proteolysis after mitogen stimulation has been identified.

Full Text - A second RING to destroy p27Kip1 | PDF (158 KB) - A second RING to destroy p27Kip1

See also: Letter by Kamura et al.

Invasive growth: A two-way street for semaphorin signalling - pp1155 - 1157

Paolo M. Comoglio, Luca Tamagnone & Silvia Giordano

doi:10.1038/ncb1204-1155

Growing evidence suggests that semaphorins — known to provide directional cues during axon guidance — also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.

Full Text - Invasive growth: A two-way street for semaphorin signalling | PDF (224 KB) - Invasive growth: A two-way street for semaphorin signalling

See also: Letter by Toyofuku et al.

Progressing actin: Formin as a processive elongation machine - pp1158 - 1159

David R. Kovar & Thomas D. Pollard

doi:10.1038/ncb1204-1158

Formins are a family of structurally conserved proteins that regulate the assembly of the fast-growing end of actin filaments. New work shows that the molecular mechanism of formin function is conserved but that the rates of the reactions vary within and between species to such a degree that the mechanisms of various formin family members may seem to differ qualitatively.

Full Text - Progressing actin: Formin as a processive elongation machine | PDF (248 KB) - Progressing actin: Formin as a processive elongation machine

It's about (molecular) time - p1161

Ravi Allada reviews Molecular Biology of Circadian Rhythms by Amita Sehgal

doi:10.1038/ncb1204-1161

Full Text - It's about (molecular) time | PDF (95 KB) - It's about (molecular) time

Cell of the month: Transformed human epithelial cells - p1163

José Moreira

doi:10.1038/ncb1204-1163

Full Text - Cell of the month: Transformed human epithelial cells | PDF (524 KB) - Cell of the month: Transformed human epithelial cells

Nuclear actin and myosin I are required for RNA polymerase I transcription - pp1165 - 1172

Vlada V. Philimonenko, Jian Zhao, Sebastian Iben, Hana Dingová, Katarína Kyselá, Michal Kahle, Hanswalter Zentgraf, Wilma A. Hofmann, Primal de Lanerolle, Pavel Hozák & Ingrid Grummt

doi:10.1038/ncb1190

Abstract - | Full Text - Nuclear actin and myosin I are required for RNA polymerase I transcription | PDF (484 KB) - Nuclear actin and myosin I are required for RNA polymerase I transcription

A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans - pp1173 - 1179

Assunta Croce, Giuseppe Cassata, Andrea Disanza, Maria Cristina Gagliani, Carlo Tacchetti, Maria Grazia Malabarba, Marie-France Carlier, Giorgio Scita, Ralf Baumeister & Pier Paolo Di Fiore

doi:10.1038/ncb1198

First Paragraph - | Full Text - A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans | PDF (825 KB) - A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans | Supplementary information

See also: News and Views by Higgs

Eps8 controls actin-based motility by capping the barbed ends of actin filaments - pp1180 - 1188

Andrea Disanza, Marie-France Carlier, Theresia E. B. Stradal, Dominique Didry, Emanuela Frittoli, Stefano Confalonieri, Assunta Croce, Jurgen Wehland, Pier Paolo Di Fiore & Giorgio Scita

doi:10.1038/ncb1199

First Paragraph - | Full Text - Eps8 controls actin-based motility by capping the barbed ends of actin filaments | PDF (1,255 KB) - Eps8 controls actin-based motility by capping the barbed ends of actin filaments | Supplementary information

See also: News and Views by Higgs

Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles - pp1189 - 1194

Stefan Otte & Charles Barlowe

doi:10.1038/ncb1195

First Paragraph - | Full Text - Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles | PDF (471 KB) - Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles | Supplementary information

Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes - pp1195 - 1203

Taruho S. Kuroda & Mitsunori Fukuda

doi:10.1038/ncb1197

First Paragraph - | Full Text - Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes | PDF (1,756 KB) - Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes | Supplementary information

Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling - pp1204 - 1211

Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Masanori Yabuki, Koichiro Harada, Masatsugu Hori & Hitoshi Kikutani

doi:10.1038/ncb1193

First Paragraph - | Full Text - Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling | PDF (3,021 KB) - Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling | Supplementary information

See also: News and Views by Comoglio et al.

Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin - pp1212 - 1220

Si Wan Kim, Jae-Il Park, Christopher M. Spring, Amy K. Sater, Hong Ji, Abena A. Otchere, Juliet M. Daniel & Pierre D. McCrea

doi:10.1038/ncb1191

First Paragraph - | Full Text - Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin | PDF (594 KB) - Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin | Supplementary information

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes - pp1221 - 1228

Shigeomi Shimizu, Toku Kanaseki, Noboru Mizushima, Takeshi Mizuta, Satoko Arakawa-Kobayashi, Craig B. Thompson & Yoshihide Tsujimoto

doi:10.1038/ncb1192

First Paragraph - | Full Text - Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes | PDF (1,343 KB) - Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes | Supplementary information

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27^Kip1 at G1 phase - pp1229 - 1235

Takumi Kamura, Taichi Hara, Masaki Matsumoto, Noriko Ishida, Fumihiko Okumura, Shigetsugu Hatakeyama, Minoru Yoshida, Keiko Nakayama & Keiichi I. Nakayama

doi:10.1038/ncb1194

First Paragraph - | Full Text - Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase | PDF (848 KB) - Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase | Supplementary information

See also: News and Views by Hengst

The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci - pp1236 - 1244

Raymond A. Poot, Ludmila Bozhenok, Debbie L.C. van den Berg, Søren Steffensen, Fernando Ferreira, Margaret Grimaldi, Nick Gilbert, Joao Ferreira & Patrick D. Varga-Weisz

doi:10.1038/ncb1196

First Paragraph - | Full Text - The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci | PDF (1,032 KB) - The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci | Supplementary information

Intra-nuclear microtubules and a mitotic spindle orientation checkpoint - pp1245 - 1246

Sabina Zimmerman, Rafael R. Daga & Fred Chang

doi:10.1038/ncb1200

Abstract - | Full Text - Intra-nuclear microtubules and a mitotic spindle orientation checkpoint | PDF (322 KB) - Intra-nuclear microtubules and a mitotic spindle orientation checkpoint | Supplementary information