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Nature Cell Biology 6, 1155–1157 (1 December 2004) | doi:10.1038/ncb1204-1155

Invasive growth: A two-way street for semaphorin signalling

Paolo M. Comoglio , Luca Tamagnone & Silvia Giordano

With few notable exceptions, the biological response is unidirectional for most signal–receptor systems and is transduced by the receptor. Indeed, in the case of semaphorins, most studies so far have found that plexins mediate the signalling outcome.