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Nature Cell Biology 6, 1153–1155 (1 December 2004) | doi:10.1038/ncb1204-1153
A second RING to destroy p27Kip1
Abstract
Regulated degradation of proteins by the ubiquitin–proteasome system is a crucial mechanism that drives progression through the cell cycle. Ubiquitination involves an enzymatic cascade that results in ubiquitin being covalently attached to a lysine residue on the substrate.
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