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Letter
Nature Cell Biology 6, 1180–1188 (1 December 2004) | doi:10.1038/ncb1199
Eps8 controls actin-based motility by capping the barbed ends of actin filaments
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Abstract
Actin filament barbed-end capping proteins are essential for cell motility, as they regulate the growth of actin filaments to generate propulsive force. One family of capping proteins, whose prototype is gelsolin, shares modular architecture, mechanism of action, and regulation through signalling-dependent mechanisms, such as Ca2+ or phosphatidylinositol-4,5-phosphate binding.
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