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Letter
Nature Cell Biology 6, 1173–1179 (1 December 2004) | doi:10.1038/ncb1198
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans
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Abstract
Redundant gene function frequently hampers investigations of the physiological roles of mammalian proteins. This is the case for Eps8, a receptor tyrosine kinase (RTK) substrate that participates in the activation of the Rac-specific guanine nucleotide-exchange function of Sos1 (refs 2–5), thereby regulating actin remodelling by RTKs.
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