News and Views
Nature Cell Biology 6, 1155 - 1157 (2004)
doi:10.1038/ncb1204-1155
Invasive growth: A two-way street for semaphorin signalling
Paolo M. Comoglio1, Luca Tamagnone1 & Silvia Giordano1
- Paolo M. Comoglio, Luca Tamagnone and Silvia Giordano are in the Division of Molecular Oncology, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo (Torino), Italy. e-mail: paolo.comoglio@ircc.it
Abstract
Growing evidence suggests that semaphorins — known to provide directional cues during axon guidance — also provide regulatory signals for cell migration during tissue morphogenesis. During heart development, it is crucial that semaphorins can signal bidirectionally, functioning as both a ligand and a receptor. Through these distinct signalling pathways, semaphorins can provide both 'stop' and 'go' signals for cell motility and invasive growth.
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