1. Ludger Hengst is at the Max-Planck-Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. e-mail: hengst@biochem.mpg.de

Abstract

The cell cycle regulator p27^Kip1 must be degraded to permit cell division. Degradation is moderate in G1 phase, but is enhanced in S-phase. Now, a novel ubiquitin ligase that can ubiquitinate p27 leading to its proteolysis after mitogen stimulation has been identified.

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