Brief Communication abstract
Nature Cell Biology 6, 1245 - 1246 (2004)
Published online: 1 December 2004 | doi:10.1038/ncb1200
Intra-nuclear microtubules and a mitotic spindle orientation checkpoint
Sabina Zimmerman1,2, Rafael R. Daga1,2 & Fred Chang1
Cells of the fission yeast Schizosaccharomyces pombe have a checkpoint mechanism that reportedly monitors the orientation of the mitotic spindle. Astral microtubules in pre-anaphase spindles are thought to contact the contractile actin ring at the plasma membrane in order to rotate the spindle and to sense spindle orientation. Here, we show that these microtubules are actually inside the nuclear envelope.
- Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.
- These authors contributed equally to this work.
Correspondence to: Fred Chang1 e-mail: fc99@columbia.edu
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