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Cell Biology of Disease
November 2004 Contents Archive
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Editorial

Focus on Cell Biology of disease

A prize for protein degradation p1011

doi:10.1038/ncb1104-1011


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News and Views

Actin's many actions start at the genes pp1013 - 1014

Werner W. Franke

doi:10.1038/ncb1104-1013

Over more than three decades, sporadic and circumstantial evidence has accumulated to suggest that nuclear actin has crucial functions in RNA polymerase II-based transcription. Now, using a biochemical approach, beta-actin has been identified as a highly specific, constitutive component of the active transcriptional complex required for formation of the pre-initiation transcription complex.

See also: Article by Hofmann et al.


MRL proteins: Leading Ena/VASP to Ras GTPases pp1015 - 1017

John A. Legg & Laura M. Machesky

doi:10.1038/ncb1104-1015

The MRL protein family is emerging as a new connection between signalling, adhesion and cell motility. Two members, lamellipodin and RIAM, can regulate both actin assembly and cell adhesion, which raises many questions about how their interactions with Ena/VASP proteins, Ras-related GTPases and membranes orchestrate these key processes.


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Book Review

Focus on Cell Biology of disease

When cells stash their trash p1019

Anthony H. Futerman & Gerrit van Meer review Lysosomal Disorders of the Brain by Frances Platt & Steven Walkley

doi:10.1038/ncb1104-1019


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Perspective

Focus on Cell Biology of disease

Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine pp1021 - 1025

Philippe A. Halban

doi:10.1038/ncb1104-1021


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Reviews

Focus on Cell Biology of disease

Subversion of phosphoinositide metabolism by intracellular bacterial pathogens pp1026 - 1033

Javier Pizarro-Cerdá & Pascale Cossart

doi:10.1038/ncb1104-1026


Focus on Cell Biology of disease

The many faces of filamin: A versatile molecular scaffold for cell motility and signalling pp1034 - 1038

Yuanyi Feng & Christopher A. Walsh

doi:10.1038/ncb1104-1034


Focus on Cell Biology of disease

Ion channels: Function unravelled by dysfunction pp1039 - 1047

Thomas J. Jentsch, Christian A. Hübner & Jens C. Fuhrmann

doi:10.1038/ncb1104-1039


Focus on Cell Biology of disease

RNA and microRNAs in fragile X mental retardation pp1048 - 1053

Peng Jin, Reid S. Alisch & Stephen T. Warren

doi:10.1038/ncb1104-1048


Focus on Cell Biology of disease

Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases pp1054 - 1061

Dennis J. Selkoe

doi:10.1038/ncb1104-1054


Focus on Cell Biology of disease

A-type lamins: Guardians of the soma? pp1062 - 1067

Chris J. Hutchison & Howard J. Worman

doi:10.1038/ncb1104-1062


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Cell of the Month

Cell of the month: Unravelling the secrets of the crypts p1069

Cécile Chalouni

doi:10.1038/ncb1104-1069


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Articles

Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments pp1071 - 1081

Alvar Trucco, Roman S. Polishchuk, Oliviano Martella, Alessio Di Pentima, Aurora Fusella, Daniele Di Giandomenico, Enrica San Pietro, Galina V. Beznoussenko, Elena V. Polishchuk, Massimiliano Baldassarre, Roberto Buccione, Willie J. C. Geerts, Abraham J. Koster, Koert N. J. Burger, Alexander A. Mironov & Alberto Luini

doi:10.1038/ncb1180


A dermal niche for multipotent adult skin-derived precursor cells pp1082 - 1093

Karl J. L. Fernandes, Ian A. McKenzie, Pleasantine Mill, Kristen M. Smith, Mahnaz Akhavan, Fanie Barnabé-Heider, Jeff Biernaskie, Adrienne Junek, Nao R. Kobayashi, Jean G. Toma, David R. Kaplan, Patricia A. Labosky, Victor Rafuse, Chi-Chung Hui & Freda D. Miller

doi:10.1038/ncb1181


Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II pp1094 - 1101

Wilma A. Hofmann, Ljuba Stojiljkovic, Beata Fuchsova, Gabriela M. Vargas, Evangelos Mavrommatis, Vlada Philimonenko, Katarina Kysela, James A. Goodrich, James L. Lessard, Thomas J. Hope, Pavel Hozak & Primal de Lanerolle

doi:10.1038/ncb1182

See also: News and Views by Franke


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Letters

Synaptobrevin is essential for fast synaptic-vesicle endocytosis pp1102 - 1108

Ferenc Deák, Susanne Schoch, Xinran Liu, Thomas C. Südhof & Ege T. Kavalali

doi:10.1038/ncb1185


Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons pp1109 - 1113

Joshua J. Snow, Guangshuo Ou, Amy L. Gunnarson, M. Regina S. Walker, H. Mimi Zhou, Ingrid Brust-Mascher & Jonathan M. Scholey

doi:10.1038/ncb1186


Mapping the dynamic organization of the nuclear pore complex inside single living cells pp1114 - 1121

Gwénaël Rabut, Valérie Doye & Jan Ellenberg

doi:10.1038/ncb1184


Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive pp1122 - 1128

Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A. Rüegg, Alan Hall & Michael N. Hall

doi:10.1038/ncb1183


Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response pp1129 - 1134

Weiming Xu, Lizhi Liu, Ian G. Charles & Salvador Moncada

doi:10.1038/ncb1188


A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 pp1135 - 1141

Chikashi Obuse, Osamu Iwasaki, Tomomi Kiyomitsu, Gohta Goshima, Yusuke Toyoda & Mitsuhiro Yanagida

doi:10.1038/ncb1187


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Brief Communication

Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast pp1142 - 1144

Tetsuya Takeda, Toshimitsu Kawate & Fred Chang

doi:10.1038/ncb1189


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