Focus on Cell Biology of disease

A prize for protein degradation - p1011

doi:10.1038/ncb1104-1011

Full Text - A prize for protein degradation | PDF (122 KB) - A prize for protein degradation

Actin's many actions start at the genes - pp1013 - 1014

Werner W. Franke

doi:10.1038/ncb1104-1013

Over more than three decades, sporadic and circumstantial evidence has accumulated to suggest that nuclear actin has crucial functions in RNA polymerase II-based transcription. Now, using a biochemical approach, -actin has been identified as a highly specific, constitutive component of the active transcriptional complex required for formation of the pre-initiation transcription complex.

Full Text - Actin's many actions start at the genes | PDF (413 KB) - Actin's many actions start at the genes

See also: Article by Hofmann et al.

MRL proteins: Leading Ena/VASP to Ras GTPases - pp1015 - 1017

John A. Legg & Laura M. Machesky

doi:10.1038/ncb1104-1015

The MRL protein family is emerging as a new connection between signalling, adhesion and cell motility. Two members, lamellipodin and RIAM, can regulate both actin assembly and cell adhesion, which raises many questions about how their interactions with Ena/VASP proteins, Ras-related GTPases and membranes orchestrate these key processes.

Full Text - MRL proteins: Leading Ena/VASP to Ras GTPases | PDF (413 KB) - MRL proteins: Leading Ena/VASP to Ras GTPases

Focus on Cell Biology of disease

When cells stash their trash - p1019

Anthony H. Futerman & Gerrit van Meer review Lysosomal Disorders of the Brain by Frances Platt & Steven Walkley

doi:10.1038/ncb1104-1019

Full Text - When cells stash their trash | PDF (119 KB) - When cells stash their trash

Focus on Cell Biology of disease

Cellular sources of new pancreatic cells and therapeutic implications for regenerative medicine - pp1021 - 1025

Philippe A. Halban

doi:10.1038/ncb1104-1021

Abstract - | Full Text - Cellular sources of new pancreatic cells and therapeutic implications for regenerative medicine | PDF (269 KB) - Cellular sources of new pancreatic cells and therapeutic implications for regenerative medicine

Focus on Cell Biology of disease

Subversion of phosphoinositide metabolism by intracellular bacterial pathogens - pp1026 - 1033

Javier Pizarro-Cerdá & Pascale Cossart

doi:10.1038/ncb1104-1026

Abstract - | Full Text - Subversion of phosphoinositide metabolism by intracellular bacterial pathogens | PDF (358 KB) - Subversion of phosphoinositide metabolism by intracellular bacterial pathogens

Focus on Cell Biology of disease

The many faces of filamin: A versatile molecular scaffold for cell motility and signalling - pp1034 - 1038

Yuanyi Feng & Christopher A. Walsh

doi:10.1038/ncb1104-1034

Abstract - | Full Text - The many faces of filamin: A versatile molecular scaffold for cell motility and signalling | PDF (335 KB) - The many faces of filamin: A versatile molecular scaffold for cell motility and signalling

Focus on Cell Biology of disease

Ion channels: Function unravelled by dysfunction - pp1039 - 1047

Thomas J. Jentsch, Christian A. Hübner & Jens C. Fuhrmann

doi:10.1038/ncb1104-1039

Abstract - | Full Text - Ion channels: Function unravelled by dysfunction | PDF (329 KB) - Ion channels: Function unravelled by dysfunction

Focus on Cell Biology of disease

RNA and microRNAs in fragile X mental retardation - pp1048 - 1053

Peng Jin, Reid S. Alisch & Stephen T. Warren

doi:10.1038/ncb1104-1048

Abstract - | Full Text - RNA and microRNAs in fragile X mental retardation | PDF (328 KB) - RNA and microRNAs in fragile X mental retardation

Focus on Cell Biology of disease

Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases - pp1054 - 1061

Dennis J. Selkoe

doi:10.1038/ncb1104-1054

Abstract - | Full Text - Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases | PDF (341 KB) - Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases

Focus on Cell Biology of disease

A-type lamins: Guardians of the soma? - pp1062 - 1067

Chris J. Hutchison & Howard J. Worman

doi:10.1038/ncb1104-1062

Abstract - | Full Text - A-type lamins: Guardians of the soma? | PDF (352 KB) - A-type lamins: Guardians of the soma?

Cell of the month: Unravelling the secrets of the crypts - p1069

Cécile Chalouni

doi:10.1038/ncb1104-1069

Full Text - Cell of the month: Unravelling the secrets of the crypts | PDF (683 KB) - Cell of the month: Unravelling the secrets of the crypts

Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments - pp1071 - 1081

Alvar Trucco, Roman S. Polishchuk, Oliviano Martella, Alessio Di Pentima, Aurora Fusella, Daniele Di Giandomenico, Enrica San Pietro, Galina V. Beznoussenko, Elena V. Polishchuk, Massimiliano Baldassarre, Roberto Buccione, Willie J. C. Geerts, Abraham J. Koster, Koert N. J. Burger, Alexander A. Mironov & Alberto Luini

doi:10.1038/ncb1180

Abstract - | Full Text - Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments | PDF (3,053 KB) - Secretory traffic triggers the formation of tubular continuities across Golgi sub-compartments | Supplementary information

A dermal niche for multipotent adult skin-derived precursor cells - pp1082 - 1093

Karl J. L. Fernandes, Ian A. McKenzie, Pleasantine Mill, Kristen M. Smith, Mahnaz Akhavan, Fanie Barnabé-Heider, Jeff Biernaskie, Adrienne Junek, Nao R. Kobayashi, Jean G. Toma, David R. Kaplan, Patricia A. Labosky, Victor Rafuse, Chi-Chung Hui & Freda D. Miller

doi:10.1038/ncb1181

Abstract - | Full Text - A dermal niche for multipotent adult skin-derived precursor cells | PDF (2,676 KB) - A dermal niche for multipotent adult skin-derived precursor cells | Supplementary information

Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II - pp1094 - 1101

Wilma A. Hofmann, Ljuba Stojiljkovic, Beata Fuchsova, Gabriela M. Vargas, Evangelos Mavrommatis, Vlada Philimonenko, Katarina Kysela, James A. Goodrich, James L. Lessard, Thomas J. Hope, Pavel Hozak & Primal de Lanerolle

doi:10.1038/ncb1182

Abstract - | Full Text - Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II | PDF (703 KB) - Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II | Supplementary information

See also: News and Views by Franke

Synaptobrevin is essential for fast synaptic-vesicle endocytosis - pp1102 - 1108

Ferenc Deák, Susanne Schoch, Xinran Liu, Thomas C. Südhof & Ege T. Kavalali

doi:10.1038/ncb1185

First Paragraph - | Full Text - Synaptobrevin is essential for fast synaptic-vesicle endocytosis | PDF (770 KB) - Synaptobrevin is essential for fast synaptic-vesicle endocytosis | Supplementary information

Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons - pp1109 - 1113

Joshua J. Snow, Guangshuo Ou, Amy L. Gunnarson, M. Regina S. Walker, H. Mimi Zhou, Ingrid Brust-Mascher & Jonathan M. Scholey

doi:10.1038/ncb1186

First Paragraph - | Full Text - Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons | PDF (766 KB) - Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons | Supplementary information

Mapping the dynamic organization of the nuclear pore complex inside single living cells - pp1114 - 1121

Gwénaël Rabut, Valérie Doye & Jan Ellenberg

doi:10.1038/ncb1184

First Paragraph - | Full Text - Mapping the dynamic organization of the nuclear pore complex inside single living cells | PDF (1,553 KB) - Mapping the dynamic organization of the nuclear pore complex inside single living cells | Supplementary information

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive - pp1122 - 1128

Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A. Rüegg, Alan Hall & Michael N. Hall

doi:10.1038/ncb1183

First Paragraph - | Full Text - Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive | PDF (662 KB) - Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive | Supplementary information

Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response - pp1129 - 1134

Weiming Xu, Lizhi Liu, Ian G. Charles & Salvador Moncada

doi:10.1038/ncb1188

First Paragraph - | Full Text - Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response | PDF (543 KB) - Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response | Supplementary information

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 - pp1135 - 1141

Chikashi Obuse, Osamu Iwasaki, Tomomi Kiyomitsu, Gohta Goshima, Yusuke Toyoda & Mitsuhiro Yanagida

doi:10.1038/ncb1187

First Paragraph - | Full Text - A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 | PDF (1,152 KB) - A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 | Supplementary information

Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast - pp1142 - 1144

Tetsuya Takeda, Toshimitsu Kawate & Fred Chang

doi:10.1038/ncb1189

Abstract - | Full Text - Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast | PDF (531 KB) - Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast | Supplementary information