Review abstract
Nature Cell Biology 6, 1048 - 1053 (2004)
doi:10.1038/ncb1104-1048
RNA and microRNAs in fragile X mental retardation
Peng Jin1, Reid S. Alisch1 & Stephen T. Warren2
Abstract
Fragile X syndrome is caused by the loss of an RNA-binding protein called FMRP (for fragile X mental retardation protein). FMRP seems to influence synaptic plasticity through its role in mRNA transport and translational regulation. Recent advances include the identification of mRNA ligands, FMRP-mediated mRNA transport and the neuronal consequence of FMRP deficiency. FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general.
- Peng Jin and Reid S. Alisch are at the Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
- Stephen T. Warren is at the Department of Human Genetics, and the Departments of Pediatrics and Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
Correspondence to: Stephen T. Warren2 e-mail: swarren@emory.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Reducing glutamate signaling pays off in fragile XNature Medicine News and Views (01 Mar 2008)
A new regulatory pathway for fragile X syndrome?Nature Medicine News and Views (01 Nov 2002)
See all 4 matches for News And ViewsRESEARCH
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathwayNature Neuroscience Article (01 Feb 2004)
See all 18 matches for Research
