John A. Legg and Laura M. Machesky are at the University of Birmingham School of Biosciences, Division of Molecular Cell Biology, Birmingham, B15 2TT, UK. l.m.machesky@bham.ac.uk
The MRL protein family is emerging as a new connection between signalling, adhesion and cell motility. Two members, lamellipodin and RIAM, can regulate both actin assembly and cell adhesion, which raises many questions about how their interactions with Ena/VASP proteins, Ras-related GTPases and membranes orchestrate these key processes.
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