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Nature Cell Biology 6, 1013 - 1014 (2004)
doi:10.1038/ncb1104-1013
Actin's many actions start at the genes
Werner W. Franke1
- Werner W. Franke is in the Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. e-mail: w.franke@dkfz.de
Abstract
Over more than three decades, sporadic and circumstantial evidence has accumulated to suggest that nuclear actin has crucial functions in RNA polymerase II-based transcription. Now, using a biochemical approach, 
-actin has been identified as a highly specific, constitutive component of the active transcriptional complex required for formation of the pre-initiation transcription complex.
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