Images to reveal all? - p909

doi:10.1038/ncb1004-909

Full Text - Images to reveal all? | PDF (65 KB) - Images to reveal all?

Growth comes of age - p911

Iswar K. Hariharan reviews Cell Growth: Control of Cell Size by Michael N. Hall, Martin Raff & George Thomas

doi:10.1038/ncb1004-911

Full Text - Growth comes of age | PDF (90 KB) - Growth comes of age

GSK-3 sets Snail's pace - pp913 - 915

Karni Schlessinger & Alan Hall

doi:10.1038/ncb1004-913

Snail, a transcription factor that promotes epithelial-to-mesenchymal transitions during development, has also been implicated in human cancer. A new mechanism in which GSK-3 phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.

Full Text - GSK-3 sets Snail's pace | PDF (160 KB) - GSK-3 sets Snail's pace

See also: Article by Zhou et al.

Crossing the tracks - p915

Jon Reynolds

doi:10.1038/ncb1004-915

Full Text - Crossing the tracks | PDF (107 KB) - Crossing the tracks

Refocusing on BRCA1 - pp916 - 917

Alan Ashworth

doi:10.1038/ncb1004-916

A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.

Full Text - Refocusing on BRCA1 | PDF (114 KB) - Refocusing on BRCA1

See also: Article by ElShamy & Livingston

Hauling t-SNAREs on the microtubule highway - pp918 - 919

R. Grace Zhai & Hugo J. Bellen

doi:10.1038/ncb1004-918

Microtubule-mediated transport is essential for neuronal viability, neurite extension, synapse formation and synaptic function. Now a new kinesin receptor, syntabulin, has been identified that controls transport of the t-SNARE syntaxin along microtubules.

Full Text - Hauling t-SNAREs on the microtubule highway | PDF (115 KB) - Hauling t-SNAREs on the microtubule highway

See also: Article by Su et al.

Nuclear transfer: Epigenetics pays a visit - pp920 - 922

Naoyuki Fujita & Paul A. Wade

doi:10.1038/ncb1004-920

Nuclear transfer, an essential step in animal cloning, results in the reprogramming of nuclei from a restricted, somatic cell programme to the totipotent pattern typical of the early embryo. A key variable in the success of cloning could be the resetting of the epigenetic status of the donor nucleus, including patterns of DNA methylation. New experiments offer insights into this poorly understood process.

Full Text - Nuclear transfer: Epigenetics pays a visit | PDF (125 KB) - Nuclear transfer: Epigenetics pays a visit

See also: Letter by Simonsson & Gurdon

Maintaining integrity - pp923 - 928

Yosef Shiloh & Alan R. Lehmann

doi:10.1038/ncb1004-923

Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.

Full Text - Maintaining integrity | PDF (318 KB) - Maintaining integrity

Cell of the month: Microtubules in mouse neurons - p929

Anna Cariboni

doi:10.1038/ncb1004-929

Full Text - Cell of the month: Microtubules in mouse neurons | PDF (293 KB) - Cell of the month: Microtubules in mouse neurons

Dual regulation of Snail by GSK-3-mediated phosphorylation in control of epithelial–mesenchymal transition - pp931 - 940

Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz & Mien-Chie Hung

doi:10.1038/ncb1173

Abstract - | Full Text - Dual regulation of Snail by GSK-3-mediated phosphorylation in control of epithelial–mesenchymal transition | PDF (2,255 KB) - Dual regulation of Snail by GSK-3-mediated phosphorylation in control of epithelial–mesenchymal transition | Supplementary information

See also: News and Views by Schlessinger & Hall

Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons - pp941 - 953

Qingning Su, Qian Cai, Claudia Gerwin, Carolyn L. Smith & Zu-Hang Sheng

doi:10.1038/ncb1169

Abstract - | Full Text - Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons | PDF (2,392 KB) - Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons | Supplementary information

See also: News and Views by Zhai & Bellen

Identification of BRCA1-IRIS, a BRCA1 locus product - pp954 - 967

Wael M. ElShamy & David M. Livingston

doi:10.1038/ncb1171

Abstract - | Full Text - Identification of BRCA1-IRIS, a BRCA1 locus product | PDF (2,365 KB) - Identification of BRCA1-IRIS, a BRCA1 locus product | Supplementary information

See also: News and Views by Ashworth

A new effector pathway links ATM kinase with the DNA damage response - pp968 - 976

Constantinos Demonacos, Marija Krstic-Demonacos, Linda Smith, Danmei Xu, Darran P. O'Connor, Martin Jansson & Nicholas B. La Thangue

doi:10.1038/ncb1170

Abstract - | Full Text - A new effector pathway links ATM kinase with the DNA damage response | PDF (1,456 KB) - A new effector pathway links ATM kinase with the DNA damage response | Supplementary information

Calpain-mediated proteolysis of talin regulates adhesion dynamics - pp977 - 983

Santos J. Franco, Mary A. Rodgers, Benjamin J. Perrin, Jaewon Han, David A. Bennin, David R. Critchley & Anna Huttenlocher

doi:10.1038/ncb1175

First Paragraph - | Full Text - Calpain-mediated proteolysis of talin regulates adhesion dynamics | PDF (1,178 KB) - Calpain-mediated proteolysis of talin regulates adhesion dynamics | Supplementary information

DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei - pp984 - 990

Stina Simonsson & John Gurdon

doi:10.1038/ncb1176

First Paragraph - | Full Text - DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei | PDF (511 KB) - DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei

See also: News and Views by Fujita & Wade

Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex - pp991 - 996

Tatsuro S. Takahashi, Pannyun Yiu, Michael F. Chou, Steven Gygi & Johannes C. Walter

doi:10.1038/ncb1177

First Paragraph - | Full Text - Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex | PDF (348 KB) - Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex | Supplementary information

Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 - pp997 - 1002

Xavier Escoté, Meritxell Zapater, Josep Clotet & Francesc Posas

doi:10.1038/ncb1174

First Paragraph - | Full Text - Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 | PDF (927 KB) - Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 | Supplementary information

Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage - pp1003 - 1009

Jian Hu, Chad M. McCall, Tomohiko Ohta & Yue Xiong

doi:10.1038/ncb1172

First Paragraph - | Full Text - Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage | PDF (558 KB) - Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage | Supplementary information

Erratum - p1010

doi:10.1038/ncb1178

Full Text - Erratum | PDF (57 KB) - Erratum

Corrigendum - p1010

doi:10.1038/ncb1179

Full Text - Corrigendum | PDF (57 KB) - Corrigendum