Table of contents
October 2004, Volume 6 No 10 pp909-1010
About the coverEditorial
Images to reveal all? - p909
doi:10.1038/ncb1004-909
Full Text - Images to reveal all? | PDF (65 KB) - Images to reveal all?
Book Review
Growth comes of age - p911
Iswar K. Hariharan reviews Cell Growth: Control of Cell Size by Michael N. Hall, Martin Raff & George Thomas
doi:10.1038/ncb1004-911
Full Text - Growth comes of age | PDF (90 KB) - Growth comes of age
News and Views
GSK-3
sets Snail's pace - pp913 - 915
Karni Schlessinger & Alan Hall
doi:10.1038/ncb1004-913
Snail, a transcription factor that promotes epithelial-to-mesenchymal transitions during development, has also been implicated in human cancer. A new mechanism in which GSK-3
phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.
Full Text - GSK-3
sets Snail's pace | PDF (160 KB) - GSK-3
sets Snail's pace
See also: Article by Zhou et al.
Crossing the tracks - p915
Jon Reynolds
doi:10.1038/ncb1004-915
Full Text - Crossing the tracks | PDF (107 KB) - Crossing the tracks
Refocusing on BRCA1 - pp916 - 917
Alan Ashworth
doi:10.1038/ncb1004-916
A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.
Full Text - Refocusing on BRCA1 | PDF (114 KB) - Refocusing on BRCA1
See also: Article by ElShamy & Livingston
Hauling t-SNAREs on the microtubule highway - pp918 - 919
R. Grace Zhai & Hugo J. Bellen
doi:10.1038/ncb1004-918
Microtubule-mediated transport is essential for neuronal viability, neurite extension, synapse formation and synaptic function. Now a new kinesin receptor, syntabulin, has been identified that controls transport of the t-SNARE syntaxin along microtubules.
Full Text - Hauling t-SNAREs on the microtubule highway | PDF (115 KB) - Hauling t-SNAREs on the microtubule highway
See also: Article by Su et al.
Nuclear transfer: Epigenetics pays a visit - pp920 - 922
Naoyuki Fujita & Paul A. Wade
doi:10.1038/ncb1004-920
Nuclear transfer, an essential step in animal cloning, results in the reprogramming of nuclei from a restricted, somatic cell programme to the totipotent pattern typical of the early embryo. A key variable in the success of cloning could be the resetting of the epigenetic status of the donor nucleus, including patterns of DNA methylation. New experiments offer insights into this poorly understood process.
Full Text - Nuclear transfer: Epigenetics pays a visit | PDF (125 KB) - Nuclear transfer: Epigenetics pays a visit
See also: Letter by Simonsson & Gurdon
Meeting Report
Maintaining integrity - pp923 - 928
Yosef Shiloh & Alan R. Lehmann
doi:10.1038/ncb1004-923
Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.
Full Text - Maintaining integrity | PDF (318 KB) - Maintaining integrity
Cell of the Month
Cell of the month: Microtubules in mouse neurons - p929
Anna Cariboni
doi:10.1038/ncb1004-929
Full Text - Cell of the month: Microtubules in mouse neurons | PDF (293 KB) - Cell of the month: Microtubules in mouse neurons
Articles
Dual regulation of Snail by GSK-3
-mediated phosphorylation in control of epithelial–mesenchymal transition - pp931 - 940
Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz & Mien-Chie Hung
doi:10.1038/ncb1173
Abstract - | Full Text - Dual regulation of Snail by GSK-3
-mediated phosphorylation in control of epithelial–mesenchymal transition | PDF (2,255 KB) - Dual regulation of Snail by GSK-3
-mediated phosphorylation in control of epithelial–mesenchymal transition | Supplementary information
See also: News and Views by Schlessinger & Hall
Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons - pp941 - 953
Qingning Su, Qian Cai, Claudia Gerwin, Carolyn L. Smith & Zu-Hang Sheng
doi:10.1038/ncb1169
Abstract - | Full Text - Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons | PDF (2,392 KB) - Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons | Supplementary information
See also: News and Views by Zhai & Bellen
Identification of BRCA1-IRIS, a BRCA1 locus product - pp954 - 967
Wael M. ElShamy & David M. Livingston
doi:10.1038/ncb1171
Abstract - | Full Text - Identification of BRCA1-IRIS, a BRCA1 locus product | PDF (2,365 KB) - Identification of BRCA1-IRIS, a BRCA1 locus product | Supplementary information
See also: News and Views by Ashworth
A new effector pathway links ATM kinase with the DNA damage response - pp968 - 976
Constantinos Demonacos, Marija Krstic-Demonacos, Linda Smith, Danmei Xu, Darran P. O'Connor, Martin Jansson & Nicholas B. La Thangue
doi:10.1038/ncb1170
Abstract - | Full Text - A new effector pathway links ATM kinase with the DNA damage response | PDF (1,456 KB) - A new effector pathway links ATM kinase with the DNA damage response | Supplementary information
Letters
Calpain-mediated proteolysis of talin regulates adhesion dynamics - pp977 - 983
Santos J. Franco, Mary A. Rodgers, Benjamin J. Perrin, Jaewon Han, David A. Bennin, David R. Critchley & Anna Huttenlocher
doi:10.1038/ncb1175
First Paragraph - | Full Text - Calpain-mediated proteolysis of talin regulates adhesion dynamics | PDF (1,178 KB) - Calpain-mediated proteolysis of talin regulates adhesion dynamics | Supplementary information
DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei - pp984 - 990
Stina Simonsson & John Gurdon
doi:10.1038/ncb1176
First Paragraph - | Full Text - DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei | PDF (511 KB) - DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
See also: News and Views by Fujita & Wade
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex - pp991 - 996
Tatsuro S. Takahashi, Pannyun Yiu, Michael F. Chou, Steven Gygi & Johannes C. Walter
doi:10.1038/ncb1177
First Paragraph - | Full Text - Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex | PDF (348 KB) - Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex | Supplementary information
Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 - pp997 - 1002
Xavier Escoté, Meritxell Zapater, Josep Clotet & Francesc Posas
doi:10.1038/ncb1174
First Paragraph - | Full Text - Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 | PDF (927 KB) - Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1 | Supplementary information
Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage - pp1003 - 1009
Jian Hu, Chad M. McCall, Tomohiko Ohta & Yue Xiong
doi:10.1038/ncb1172
First Paragraph - | Full Text - Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage | PDF (558 KB) - Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage | Supplementary information


