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Letter

Nature Cell Biology 6, 977–983 (1 October 2004) | doi:10.1038/ncb1175

Calpain-mediated proteolysis of talin regulates adhesion dynamics

Santos J. Franco , Mary A. Rodgers , Benjamin J. Perrin , Jaewon Han , David A. Bennin , David R. Critchley & Anna Huttenlocher

Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress has been made in defining some of the molecular mechanisms by which adhesion disassembly is regulated, including the contributions of adhesion adaptor proteins and tyrosine kinases.