News and Views
Nature Cell Biology 6, 920 - 922 (2004)
doi:10.1038/ncb1004-920
Nuclear transfer: Epigenetics pays a visit
Naoyuki Fujita1 & Paul A. Wade1
- Naoyuki Fujita and Paul A. Wade are at the Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University, Whitehead Building Room 142, 615 Michael Street, Atlanta, GA, USA. e-mail: pwade@emory.edu
Abstract
Nuclear transfer, an essential step in animal cloning, results in the reprogramming of nuclei from a restricted, somatic cell programme to the totipotent pattern typical of the early embryo. A key variable in the success of cloning could be the resetting of the epigenetic status of the donor nucleus, including patterns of DNA methylation. New experiments offer insights into this poorly understood process.
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