News and Views
Nature Cell Biology 6, 916 - 917 (2004)
doi:10.1038/ncb1004-916
Refocusing on BRCA1
Alan Ashworth1
- Alan Ashworth is at The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. e-mail: alan.ashworth@icr.ac.uk
Abstract
A panoply of functions have been proposed for the BRCA1 cancer susceptibility protein, particularly in the response to DNA damage and in transcriptional regulation. This complexity is now exacerbated by the discovery of a distinct splice variant of BRCA1, BRCA1/IRIS, with a previously uncharacterized function in DNA replication. This has implications for understanding tumorigenesis in BRCA1 mutation carriers.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Identification of BRCA1-IRIS, a BRCA1 locus productNature Cell Biology Article (01 Oct 2004)
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sitesThe EMBO Journal Article (17 May 2006)
BRCA1 participates in DNA decatenationNature Structural & Molecular Biology Article (01 Jul 2005)
