1. Karni Schlessinger and Alan Hall are at the MRC Laboratory for Molecular Cell Biology & Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, UK. e-mail: alan.hall@ucl.ac.uk and e-mail: k.schlessinger@ucl.ac.uk

Abstract

Snail, a transcription factor that promotes epithelial-to-mesenchymal transitions during development, has also been implicated in human cancer. A new mechanism in which GSK-3 phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.

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