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Letter

Nature Cell Biology 6, 52–58 (1 January 2004) | doi:10.1038/ncb1081

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

Ajamete Kaykas , Julia Yang-Snyder , Madeleine H|[eacute]|roux , Kavita V. Shah , Michel Bouvier & Randall T. Moon

nt signalling pathways regulate cell proliferation, cell fate and morphogenetic movements. Here, we demonstrate that the Frizzled (Fz) family of Wnt receptors, similarly to G-protein-coupled receptors (GPCRs), form specific homo- and hetero-oligomers.