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Letter

Nature Cell Biology 6, 73–77 (1 January 2004) | doi:10.1038/ncb1076

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Robert Schneider , Andrew J. Bannister , Fiona A. Myers , Alan W. Thorne , Colyn Crane-Robinson & Tony Kouzarides

Lysine residues within histones can be mono-, di - or tri-methylated. In Saccharomyces cerevisiae tri-methylation of Lys 4 of histone H3 (K4/H3) correlates with transcriptional activity, but little is known about this methylation state in higher eukaryotes.