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Nature Cell Biology 6, 9–11 (1 January 2004) | doi:10.1038/ncb0104-9
Sweet control of cell migration, cytokinesis and organogenesis
Abstract
Although glycosylation of proteins is a frequent post-translational modification discovered many years ago, it is unclear why specific proteins go through this complex pathway of adding, and sometimes trimming, numerous sugars. Glycoproteins have been implicated in diverse intracellular functions from bacteria to mice, including organelle structure and function, sorting and trafficking, as well as in intercellular functions such as cell adhesion, migration, proliferation, extracellular matrix organization, differentiation and morphogenesis.
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