Molecule pages live - p1

doi:10.1038/ncb0104-1

Full Text - Molecule pages live | PDF (127 KB) - Molecule pages live

Controlling Abl: auto-inhibition and co-inhibition? - pp3 - 7

Jean Y. J. Wang

doi:10.1038/ncb0104-3

Abstract - | Full Text - Controlling Abl: auto-inhibition and co-inhibition? | PDF (204 KB) - Controlling Abl: auto-inhibition and co-inhibition?

Motoring down the molecular highway - p8

James R Sellers reviews Molecular motors by Manfred Schliwa

doi:10.1038/ncb0104-8

Full Text - Motoring down the molecular highway | PDF (96 KB) - Motoring down the molecular highway

Sweet control of cell migration, cytokinesis and organogenesis - pp9 - 11

Benjamin Podbilewicz

doi:10.1038/ncb0104-9

Why are proteins glycosylated? On the basis of new studies, I propose two models to clarify the specific functions of glycosylation in worms. The first explains how intra- and inter-cellular trafficking of an N-glycosylated disintegrin-metalloprotease guides somatic gonadal cells through their migratory route, determining the shape of an organ. The second explains how rigid coats of secreted chondroitin proteoglycans bend membranes to drive cytokinesis and epithelial invagination.

Full Text - Sweet control of cell migration, cytokinesis and organogenesis | PDF (176 KB) - Sweet control of cell migration, cytokinesis and organogenesis

Formin' adherens junctions - pp12 - 14

Sally Zigmond

doi:10.1038/ncb0104-12

Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through -catenin and -catenin. Formin1 is critically important for the formation of actin cables; it binds directly to -catenin and can even bypass the need for -catenin when targeted to -catenin.

Full Text - Formin' adherens junctions | PDF (384 KB) - Formin' adherens junctions

The centrosome yields its secrets - p14

Tim Stearns

doi:10.1038/ncb0104-14

Full Text - The centrosome yields its secrets | PDF (326 KB) - The centrosome yields its secrets

Lipid pickup and delivery - pp15 - 16

Howard Riezman & Gerrit van Meer

doi:10.1038/ncb0104-15

Intracellular organelles have specific lipid and protein compositions. Although great progress has been made concerning the mechanisms that govern the transport of proteins between organelles, little information is available about the mechanisms of inter-organellar lipid transport. New work identifies a protein that specifically transports ceramide, a precursor of sphingolipid synthesis, between intracellular organelles.

Full Text - Lipid pickup and delivery | PDF (114 KB) - Lipid pickup and delivery

No glial death with NO - pp17 - 18

Solomon H. Snyder & Sangwon Kim

doi:10.1038/ncb0104-17

Nitric oxide (NO) is one of biology's most multi-faceted molecules. In some cases, NO seems to have contradictory outcomes; for example, it has been reported to be both neurotoxic and neuroprotective. Recent work now address this conundrum, at least in neurons and glia, and describes an elegant molecular cascade whereby NO provides cytoprotection in astrocytes, but not in neurons.

Full Text - No glial death with NO | PDF (241 KB) - No glial death with NO

Cell of the month: A human neurosphere attaching to a coated surface - p19

Riccardo Cassiani Ingoni

doi:10.1038/ncb0104-19

Full Text - Cell of the month: A human neurosphere attaching to a coated surface | PDF (411 KB) - Cell of the month: A human neurosphere attaching to a coated surface

Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables - pp21 - 30

Agnieszka Kobielak, H. Amalia Pasolli & Elaine Fuchs

doi:10.1038/ncb1075

Abstract - | Full Text - Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables | PDF (1,790 KB) - Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables | Supplementary information

See also: News and Views by Zigmond

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans - pp31 - 37

Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto & Kunihiro Matsumoto

doi:10.1038/ncb1079

First Paragraph - | Full Text - An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans | PDF (3,063 KB) - An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans | Supplementary information

See also: News and Views by Podbilewicz

The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling - pp38 - 44

Ralph T. Böttcher, Nicolas Pollet, Hajo Delius & Christof Niehrs

doi:10.1038/ncb1082

First Paragraph - | Full Text - The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling | PDF (5,970 KB) - The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling | Supplementary information

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway - pp45 - 51

Angeles Almeida, Salvador Moncada & Juan P. Bolaños

doi:10.1038/ncb1080

First Paragraph - | Full Text - Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway | PDF (327 KB) - Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway | Supplementary information

See also: News and Views by Snyder & Kim

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization - pp52 - 58

Ajamete Kaykas, Julia Yang-Snyder, Madeleine Héroux, Kavita V. Shah, Michel Bouvier & Randall T. Moon

doi:10.1038/ncb1081

First Paragraph - | Full Text - Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization | PDF (4,070 KB) - Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization | Supplementary information

Late-G1 cyclin–CDK activity is essential for control of cell morphogenesis in budding yeast - pp59 - 66

Jason Moffat & Brenda Andrews

doi:10.1038/ncb1078

First Paragraph - | Full Text - Late-G1 cyclin–CDK activity is essential for control of cell morphogenesis in budding yeast | PDF (1,149 KB) - Late-G1 cyclin–CDK activity is essential for control of cell morphogenesis in budding yeast | Supplementary information

Polycomb CBX7 has a unifying role in cellular lifespan - pp67 - 72

Jesús Gil, David Bernard, Dolores Martínez & David Beach

doi:10.1038/ncb1077

First Paragraph - | Full Text - Polycomb CBX7 has a unifying role in cellular lifespan | PDF (1,135 KB) - Polycomb CBX7 has a unifying role in cellular lifespan | Supplementary information

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes - pp73 - 77

Robert Schneider, Andrew J. Bannister, Fiona A. Myers, Alan W. Thorne, Colyn Crane-Robinson & Tony Kouzarides

doi:10.1038/ncb1076

First Paragraph - | Full Text - Histone H3 lysine 4 methylation patterns in higher eukaryotic genes | PDF (209 KB) - Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Erratum - Programmed cell death: Superman meets Dr Death - p77

doi:10.1038/ncb1083

Full Text - Erratum - Programmed cell death: Superman meets Dr Death | PDF (41 KB) - Erratum - Programmed cell death: Superman meets Dr Death

Erratum: Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis - p77

doi:10.1038/ncb1084

Full Text - Erratum: Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis | PDF (47 KB) - Erratum: Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

Corrigendum: EB1 reveals mobile microtubule nucleation sites in Arabidopsis - p77

doi:10.1038/ncb1085

Full Text - Corrigendum: EB1 reveals mobile microtubule nucleation sites in Arabidopsis | PDF (45 KB) - Corrigendum: EB1 reveals mobile microtubule nucleation sites in Arabidopsis