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Letter
Nature Cell Biology 6, 59–66 (1 January 2004) | doi:10.1038/ncb1078
Late-G1 cyclin|[ndash]|CDK activity is essential for control of cell morphogenesis in budding yeast
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Abstract
The accurate spatial and temporal coordination of cell polarization with DNA replication and segregation guarantees the fidelity of genetic transmission. Here we report that in Saccharomyces cerevisiae, a build-up or burst of G1 cyclin-dependent kinase (CDK) activity through activation of the cyclin genes CLN1,2 and PCL1,2 is essential for cell morphogenesis, but not for other events associated with the G1–S-phase transition, including DNA replication.
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