Letter abstract
Nature Cell Biology 6, 31 - 37 (2003)
Published online: 21 December 2003 | doi:10.1038/ncb1079
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
Kiyoji Nishiwaki1, Yukihiko Kubota1, Yuko Chigira2, Samir Kumar Roy2, Maho Suzuki3, Mara Schvarzstein4, Yoshifumi Jigami2, Naoki Hisamoto3 & Kunihiro Matsumoto3
In the nematode Caenorhabditis elegans, the gonad acquires two U-shaped arms through the directed migration of its distal tip cells (DTCs), which are located at the tip of the growing gonad arms1. A member of the ADAM (a disintegrin and metalloprotease) family, MIG-17, regulates directional migration of DTCs: MIG-17 is synthesized and secreted from the muscle cells of the body wall, and diffuses to the gonad where it is required for DTC migration2. The mig-23 mutation causes defective migration of DTCs and interacts genetically with mig-17. Here, we report that mig-23 encodes a membrane-bound nucleoside diphosphatase (NDPase) required for glycosylation and proper localization of MIG-17. Our findings indicate that an NDPase affects organ morphogenesis through glycosylation of the MIG-17 ADAM protease.
- RIKEN Center for Developmental Biology and PRESTO, Japan Science and Technology Corporation, Chuo-ku, Kobe 650-0047, Japan.
- Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, AIST Central 6, Tsukuba 305-8566, Japan.
- Department of Molecular Biology, Graduate school of Science, Institute for Advanced Research, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa-ku, Nagoya 464-8602, Japan.
- Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Correspondence to: Kiyoji Nishiwaki1 e-mail: nishiwak@cdb.riken.go.jp
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