News and Views
Nature Cell Biology 6, 9 - 11 (2004)
doi:10.1038/ncb0104-9
Sweet control of cell migration, cytokinesis and organogenesis
Benjamin Podbilewicz1
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Benjamin Podbilewicz is at the Department of Biology, Technion-Israel Institute of Technology, Haifa, 32000, Israel, but can currently be contacted at the Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, NICHD, NIH, Bethesda MD 20892, USA.
e-mail: podbilew@tx.technion.ac.il
Abstract
Why are proteins glycosylated? On the basis of new studies, I propose two models to clarify the specific functions of glycosylation in worms. The first explains how intra- and inter-cellular trafficking of an N-glycosylated disintegrin-metalloprotease guides somatic gonadal cells through their migratory route, determining the shape of an organ. The second explains how rigid coats of secreted chondroitin proteoglycans bend membranes to drive cytokinesis and epithelial invagination.
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An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegansNature Cell Biology Letter (01 Jan 2004)
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Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesisNature Letters to Editor (22 May 2003)
